An open clinical trial of fluvoxamine treatment of psychogenic excoriation

被引:65
作者
Arnold, LM
Mutasim, DF
Dwight, MM
Lamerson, CL
Morris, EM
McElroy, SL
机构
[1] Univ Cincinnati, Med Ctr, Biol Psychiat Program, Cincinnati, OH 45267 USA
[2] Univ Cincinnati, Med Ctr, Dept Dermatol, Cincinnati, OH 45267 USA
关键词
D O I
10.1097/00004714-199902000-00005
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The purpose of this study was to examine the safety and efficacy of fluvoxamine in the treatment of psychogenic (neurotic) skin excoriation. Fourteen subjects with psychogenic excoriation were given fluvoxamine in a 12-week, open-label trial after completion of the Structured clinical Interview for DSM-IV. AU subjects met DSM-TV criteria for at least one comorbid psychiatric disorder, with mood disorder the most common. Most subjects' excoriation had features of an impulse control disorder. Both completers (N = 7) and the entire group had significant improvement on the modified Yale-Brown Obsessive Compulsive Scale but no improvement on the Hamilton Rating Scale for Depression. In the self-report data, the seven completers had significant reduction in behaviors involving the skin (e.g., scratching, picking, gouging, or squeezing) and in global assessment of symptoms. Endpoint analysis of all 14 subjects' self-report data demonstrated significant improvement in the presence of skin sensations, skin appearance and lesions, behaviors involving the skin, control over skin behavior, and global assessment. The results of this preliminary open-trial suggest that fluvoxamine may be effective in reducing psychogenic excoriation, and this effect seems to be independent of mood. Controlled studies are needed to confirm these findings.
引用
收藏
页码:15 / 18
页数:4
相关论文
共 15 条
[1]   Characteristics of 34 adults with psychogenic excoriation [J].
Arnold, LM ;
McElroy, SL ;
Mutasim, DF ;
Dwight, MM ;
Lamerson, CL ;
Morris, EM .
JOURNAL OF CLINICAL PSYCHIATRY, 1998, 59 (10) :509-514
[2]  
First M. B., 2016, USERS GUIDE SCID 5 1
[3]  
GOODMAN WK, 1989, ARCH GEN PSYCHIAT, V46, P1006
[4]  
GUPTA MA, 1993, CUTIS, V51, P386
[5]   NEUROTIC EXCORIATIONS - A REVIEW AND SOME NEW PERSPECTIVES [J].
GUPTA, MA ;
GUPTA, AK ;
HABERMAN, HF .
COMPREHENSIVE PSYCHIATRY, 1986, 27 (04) :381-386
[6]   A RATING SCALE FOR DEPRESSION [J].
HAMILTON, M .
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1960, 23 (01) :56-62
[7]   Sertraline in the treatment of neurotic excoriations and related disorders [J].
Kalivas, J ;
Kalivas, L ;
Gilman, D ;
Hayden, CT .
ARCHIVES OF DERMATOLOGY, 1996, 132 (05) :589-590
[8]  
McElroy S. L., 1993, DEPRESSION, V1, P121
[9]   Are impulse-control disorders related to bipolar disorder? [J].
McElroy, SL ;
Pope, HG ;
Keck, PE ;
Hudson, JI ;
Phillips, KA ;
Strakowski, SM .
COMPREHENSIVE PSYCHIATRY, 1996, 37 (04) :229-240
[10]  
MCELROY SL, 1994, J CLIN PSYCHIAT, V55, P33