Modulation of RNA tertiary folding by incorporation of caged nucleotides

被引：70

作者：

Höbartner, C ^{[1
]}

Silverman, SK ^{[1
]}

机构：

[1] Univ Illinois, Dept Chem, Urbana, IL 61801 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 44期

关键词：

caging; nucleobases; oligonucleotides; photolysis; RNA structures;

D O I：

10.1002/anie.200502928

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) Knock it off: Individual RNA nucleotides with a caged nucleobase were incorporated, through their phosphoramidites, into a 160-mer RNA molecule that adopts a specific tertiary structure (see picture). Position-dependent local and global effects on RNA structure were observed, and photocleavage of the caging group was seen to restore the native folding. © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：7305 / 7309

页数：5

共 58 条

[1] Remarkable morphological variability of a common RNA folding motif: The GNRA tetraloop-receptor interaction [J].