Ginsan improved Th1 immune response inhibited by gamma radiation

被引:42
作者
Han, SK
Song, JY
Yun, YS
Yi, SY
机构
[1] Korea Inst Radiol & Med Sci, Immunol Lab, Seoul 139706, South Korea
[2] Korea Inst Sci & Technol, Bioanal & Biotransformat Res Ctr, Seoul 130650, South Korea
[3] Suwon Univ, Coll Nat Sci, Suwon 445743, South Korea
[4] Microbia Corp, Tech Res Inst, Suwon 445743, South Korea
关键词
ginsan; gamma radiation; cytokines;
D O I
10.1007/BF02977803
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Gamma radiation causes suppression of the immune function, and immune properties are related to cytokine production. In the present study, the polysaccharide, Ginsan, purified from an ethanol-insoluble fraction of Ginseng (Panax ginseng C.A. Meyer, Araliaceae) water extract was studied to assess its effects on the immunosuppressive activities of gamma radiation. Ginsan was found to stimulate murine normal splenocytes by inducing the mRNA expressions of Th1 and Th2 type cytokines, and also restore the mRNA expression of IFN-gamma, Th1 cytokine, after its inhibition by whole-body gamma irradiation. Therefore, Ginsan was found to restore the T lymphocytes function that had been suppressed by gamma irradiation in allogenic MLR (mixed lymphocyte reactions). However, Ginsan exhibited no excessive stimulatory effects on the control group. The above results indicated that Ginsan may constitute a new noble agent for the improvement of gamma radiation-induced immunosuppression.
引用
收藏
页码:343 / 350
页数:8
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