HLA-G class I gene expression in normal and malignant hematopoietic cells

被引：72

作者：

Amiot, L ^{[1
]}

Onno, M ^{[1
]}

Drénou, B ^{[1
]}

Monvoisin, C ^{[1
]}

Fauchet, R ^{[1
]}

机构：

[1] Univ Rennes 1, Lab Hematol & Biol Cellules Sanguines, Fac Med, F-35043 Rennes, France

来源：

HUMAN IMMUNOLOGY | 1998年 / 59卷 / 08期

关键词：

D O I：

10.1016/S0198-8859(98)00041-X

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The class Ib HLA-G gene encodes for a molecule which is selectively expressed in fetal placental cells. Fetomaternal tolerance could be partially explained by the interactions between HLA-G molecules and KIR receptors of decidual NK cells. To determine whether the presence of HLA-G antigens might constitute a factor of immune tolerance during the tumoral process, we compared the expression of the HLA-G gene in normal and malignant hematopoietic cells. Despite a HLA-G transcriptional activity in several lymphocytes and monocytes, no antigens are found at the cell surface or in the cytosol using the specific HLA-G mAb, 87G. This lack of expression does not appear modified in malignant hematopoietic cells. However, treatment of the monohistiocytic cell line U937 with different cytokines enabled the expression of HLA-G antigens to be induced. We suggest that the potential induction of HLA-G molecules in monocytic malignant cells following secretion of cytokines may constitute a factor of immune tolerance in patients. Human Immunology 59, 524-528 (1998). (C) American Society for Histocompatibility and Immunogenetics, 1998. Published by Elsevier Science Inc.

引用

页码：524 / 528

页数：5

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