The role of extracellular vesicles in placental vascular complications

被引：12

作者：

Aharon, Anat ^{[1
,2
]}

机构：

[1] Rambam Hlth Care Campus, Dept Hematol, Microvesicles Res Lab, Thrombosis & Hemostasis Unit, IL-31096 Haifa, Israel

[2] Technion Israel Inst Technol, Bruce Rappaport Fac Med, Haifa, Israel

来源：

THROMBOSIS RESEARCH | 2015年 / 135卷

关键词：

Extracellular membrane vesicles (EVs); Exosomes; Microparticles (MPs); microRNA (miRNA); Pregnancy; Gestational vascular complications (GVC); FACTOR PATHWAY INHIBITOR; TISSUE-FACTOR; INTERCELLULAR COMMUNICATION; ACTIVATED PLATELETS; ENDOTHELIAL-CELLS; MICROPARTICLES; MICRORNAS; EXOSOMES; PREECLAMPSIA; BLOOD;

D O I：

10.1016/S0049-3848(15)50435-0

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Extracellular membrane vesicles (EVs) also termed microvesicles (MVs) are secreted from different cells, are present in the blood circulation under normal physiological conditions, and their levels increase in a wide range of disease states. EVs contain proteins, growth and apoptotic factors, DNA fragments, microRNAs as well as messenger RNAs (mRNAs); therefore, they may function as regulators in cell-cell communication and mediators of cell signaling during multiple biological processes. The current review focuses on the role of EVs in healthy pregnancy and gestational vascular complications and discusses the involvement of EVs in gene regulation, placental hemostasis and cell function that overall reflect the placental-maternal crosstalk. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：S23 / S25

页数：3

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