Autoreactive antibodies following autologous peripheral blood stem cell transplantation

被引：28

作者：

Ishikawa, F ^{[1
]}

Shigematsu, H ^{[1
]}

Gondo, H ^{[1
]}

Okamura, T ^{[1
]}

Niho, Y ^{[1
]}

机构：

[1] Kyushu Univ, Fac Med, Dept Internal Med 1, Higashi Ku, Fukuoka 8128582, Japan

来源：

BONE MARROW TRANSPLANTATION | 1998年 / 22卷 / 07期

关键词：

autoimmune; autologous; peripheral blood stem cells; transplantation; multiple myeloma;

D O I：

10.1038/sj.bmt.1701409

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

A 35-year-old woman diagnosed with multiple myeloma (IgG, lambda type, stage IIIA) received an autologous peripheral blood stem cell, transplant (PBSCT). She was euthyroid without autoreactive antibodies prior to the transplant. The patient complained of malaise, weight loss and low grade fever 1 month after transplant, despite rapid haematopoietic recovery. Thyroid function tests on day 34 revealed hyperthyroidism associated with anti-thyroid peroxidase antibody. Antinuclear antibody was also detected, and platelet-associated immunoglobulin was increased. These findings disappeared spontaneously by day 62 without treatment. Autoimmune diseases may occur transiently after autologous PBSCT.

引用

页码：729 / 731

页数：3

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