HLA DRB1*13 as a risk factor for type 1 autoimmune hepatitis in North American patients

被引：24

作者：

Czaja, Albert J. ^{[1
]}

Carpenter, Herschel A. ^{[2
]}

Moore, S. Breanndan ^{[2
]}

机构：

[1] Mayo Clin, Coll Med, Div Gastroenterol & Hepatol, Rochester, MN 55905 USA

[2] Mayo Clin, Coll Med, Dept Lab Med & Pathol, Rochester, MN USA

来源：

DIGESTIVE DISEASES AND SCIENCES | 2008年 / 53卷 / 02期

关键词：

genetic predisposition; susceptibility factor; distinctions;

D O I：

10.1007/s10620-007-9859-4

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Our goal was to determine if HLA DRB1*13 is associated with autoimmune hepatitis in North American patients. Two hundred and ten adults with definite type 1 autoimmune hepatitis were typed by DNA-based techniques, and the frequency of HLA DRB1*13 in patients without DRB1*03 and DRB1*04 was compared to that in 396 patients with eight other chronic liver diseases and 102 normal individuals. HLA DRB1*13 occurred more commonly in the autoimmune patients who lacked DRB1*03 and DRB1*04 than normal subjects who were similarly restricted (56% vs. 27%, P = 0.007). The frequency of HLA DRB1*13 was higher in autoimmune patients without DRB1*03 and DRB1*04 than in patients with other chronic liver diseases who were similarly restricted (59% vs. 32%, P = 0.01). Only patients with primary sclerosing cholangitis had a comparable occurrence of HLA DRB1*13. In conclusion, HLA DRB1*13 may be a genetic risk factor for some white North American patients with type 1 autoimmune hepatitis.

引用

页码：522 / 528

页数：7

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