Cancer chemotherapy - ribonucleases to the rescue

被引：180

作者：

Leland, PA

Raines, RT ^{[1
]}

机构：

[1] Univ Wisconsin, Dept Biochem, Madison, WI 53706 USA

[2] Univ Wisconsin, Dept Chem, Madison, WI 53706 USA

来源：

CHEMISTRY & BIOLOGY | 2001年 / 8卷 / 05期

关键词：

cancer; drug; onconase; ribonuclease; ribonuclease inhibitor;

D O I：

10.1016/S1074-5521(01)00030-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ribonucleases, once dismissed as uninteresting digestive enzymes, have been shown to have remarkable biological activities. Onconase (R), from the Northern leopard frog, is currently in clinical trials as a cancer chemotherapeutic. Recent research has revealed some key factors responsible for the cytotoxicity of ribonucleases, and may lead to a new class of drugs. (C) 2001 Published by Elsevier Science Ltd.

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收藏

页码：405 / 413

页数：9

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