Stereoselective synthesis of α-substituted serines from protected erythrulose oximes

被引:25
作者
Carda, M [1 ]
Murga, J
Rodríguez, S
González, F
Castillo, E
Marco, JA
机构
[1] Univ Jaume 1, Dept Q Inorgan & Organ, E-12080 Castellon de La Plana, Spain
[2] Univ Valencia, Dept Quim Organ, E-46100 Burjassot, Valencia, Spain
关键词
D O I
10.1016/S0957-4166(98)00146-3
中图分类号
O61 [无机化学];
学科分类号
070301 ; 081704 ;
摘要
The additions of organolithium reagents to the C=N bond of several chiral oxime ethers derived from erythrulose afforded protected amino polyols with high diastereoselectivity. Four of the latter compounds have been converted into the alpha,alpha-disubstituted alpha-amino acids (R)-2-(-)-methylserine, (S)-2-(+)-methylserine, (R)-(+)-2-phenylserine and (R)-(-)-2-n-butylserine. (C) 1998 Elsevier Science Ltd. All rights reserved.
引用
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页码:1703 / 1712
页数:10
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