Stereoselective synthesis of α-substituted serines from protected erythrulose oximes

被引：25

作者：

Carda, M ^{[1
]}

Murga, J

Rodríguez, S

González, F

Castillo, E

Marco, JA

机构：

[1] Univ Jaume 1, Dept Q Inorgan & Organ, E-12080 Castellon de La Plana, Spain

[2] Univ Valencia, Dept Quim Organ, E-46100 Burjassot, Valencia, Spain

来源：

TETRAHEDRON-ASYMMETRY | 1998年 / 9卷 / 10期

关键词：

D O I：

10.1016/S0957-4166(98)00146-3

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The additions of organolithium reagents to the C=N bond of several chiral oxime ethers derived from erythrulose afforded protected amino polyols with high diastereoselectivity. Four of the latter compounds have been converted into the alpha,alpha-disubstituted alpha-amino acids (R)-2-(-)-methylserine, (S)-2-(+)-methylserine, (R)-(+)-2-phenylserine and (R)-(-)-2-n-butylserine. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：1703 / 1712

页数：10

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