Stereoselective synthesis of α-substituted serines from protected erythrulose oximes
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Carda, M
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Univ Jaume 1, Dept Q Inorgan & Organ, E-12080 Castellon de La Plana, SpainUniv Jaume 1, Dept Q Inorgan & Organ, E-12080 Castellon de La Plana, Spain
Carda, M
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Murga, J
Rodríguez, S
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机构:Univ Jaume 1, Dept Q Inorgan & Organ, E-12080 Castellon de La Plana, Spain
Rodríguez, S
González, F
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González, F
Castillo, E
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Castillo, E
Marco, JA
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机构:Univ Jaume 1, Dept Q Inorgan & Organ, E-12080 Castellon de La Plana, Spain
Marco, JA
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[1] Univ Jaume 1, Dept Q Inorgan & Organ, E-12080 Castellon de La Plana, Spain
The additions of organolithium reagents to the C=N bond of several chiral oxime ethers derived from erythrulose afforded protected amino polyols with high diastereoselectivity. Four of the latter compounds have been converted into the alpha,alpha-disubstituted alpha-amino acids (R)-2-(-)-methylserine, (S)-2-(+)-methylserine, (R)-(+)-2-phenylserine and (R)-(-)-2-n-butylserine. (C) 1998 Elsevier Science Ltd. All rights reserved.