Randomized trial of induction chemotherapy in larynx carcinoma

被引：160

作者：

Richard, JM

Sancho-Garnier, H

Pessey, JJ

Luboinski, B

Lefebvre, JL

Dehesdin, D

Stromboni-Luboinski, M

Hill, C

机构：

[1] Inst Gustave Roussy, Dept Biostat & Epidemiol, F-94805 Villejuif, France

[2] Inst Gustave Roussy, Dept Head & Neck Oncol, F-94805 Villejuif, France

[3] CHU Rangueil, Dept Ear Nose & Throat, F-31054 Toulouse, France

[4] Ctr Oscar Lambret, Dept Head & Neck Oncol, F-59020 Lille, France

[5] CHU Rouen, Dept Head & Neck Oncol, Rouen, France

来源：

ORAL ONCOLOGY | 1998年 / 34卷 / 03期

关键词：

laryngeal carcinoma; randomized trial; induction chemotherapy; larynx preservation;

D O I：

10.1016/S1368-8375(97)00090-0

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We conducted a randomized study in patients with previously untreated advanced (T3) larynx carcinoma to compare total laryngectomy followed by radiotherapy to induction chemotherapy, followed by radiotherapy in good responders, and by total laryngectomy plus radiotherapy in poor responders. A total of 68 patients were included in the study, 36 in the induction chemotherapy group and 32 in the no chemotherapy group. 15 of the 36 patients in the induction chemotherapy group did not have a laryngectomy. Survival and disease-free survival were significantly worse in the induction chemotherapy group than in the no chemotherapy group (P = 0.006 and P = 0.02, respectively). The 2-year survival rates were 69% in the induction chemotherapy group and 84% in the no chemotherapy group. Larynx preservation for patients, selected on the basis of having responded to induction chemotherapy, cannot be considered a standard treatment at the present time. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：224 / 228

页数：5

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