Mitochondrial DNA synthesis fuels NLRP3 inflammasome

被引：22

作者：

Coll, Rebecca C. ^{[1
,2
]}

Holley, Caroline L. ^{[1
,2
]}

Schroder, Kate ^{[1
,2
]}

机构：

[1] Univ Queensland, Inst Mol Biosci, St Lucia, Qld, Australia

[2] Univ Queensland, IMB Ctr Inflammat & Dis Res, St Lucia, Qld, Australia

来源：

CELL RESEARCH | 2018年 / 28卷 / 11期

关键词：

ACTIVATION; APOPTOSIS; DAMAGE;

D O I：

10.1038/s41422-018-0093-8

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Mitochondria-derived signals are associated with NLRP3 inflammasome activation. A recent study in Nature by Zhong et al. shows that inflammasome priming drives new mitochondrial DNA synthesis, and proposes this to be a prerequisite for NLRP3 inflammasome signaling.

引用

收藏

页码：1046 / 1047

页数：2

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