The Metabolic Role of Gut Microbiota in the Development of Nonalcoholic Fatty Liver Disease and Cardiovascular Disease

被引：45

作者：

Zamparelli, Marco Sanduzzi ^{[1
]}

Compare, Debora ^{[1
]}

Coccoli, Pietro ^{[1
]}

Rocco, Alba ^{[1
]}

Nardone, Olga Maria ^{[1
]}

Marrone, Giuseppe ^{[2
]}

Gasbarrini, Antonio ^{[2
]}

Grieco, Antonio ^{[2
]}

Nardone, Gerardo ^{[2
]}

Miele, Luca ^{[2
]}

机构：

[1] Univ Naples Federico II, Gastroenterol Unit, Dept Clin Med & Surg, I-80131 Naples, Italy

[2] Univ Cattolica Sacro Cuore, Fdn Policlin Univ A Gemelli, Internal Med & Gastroenterol Area, I-00168 Rome, Italy

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2016年 / 17卷 / 08期

关键词：

gut microbiota; cardiovascular disease; NAFLD; PROTEIN-COUPLED RECEPTOR; DIET-INDUCED OBESITY; INTESTINAL MICROBIOTA; BILE-ACID; AKKERMANSIA-MUCINIPHILA; ASSOCIATION; GLUCOSE; ENDOTOXEMIA; IMPACT; AXIS;

D O I：

10.3390/ijms17081225

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The prevalence of metabolic disorders, such as type 2 diabetes (T2D), obesity, and non-alcoholic fatty liver disease (NAFLD), which are common risk factors for cardiovascular disease (CVD), has dramatically increased worldwide over the last decades. Although dietary habit is the main etiologic factor, there is an imperfect correlation between dietary habits and the development of metabolic disease. Recently, research has focused on the role of the microbiome in the development of these disorders. Indeed, gut microbiota is implicated in many metabolic functions and an altered gut microbiota is reported in metabolic disorders. Here we provide evidence linking gut microbiota and metabolic diseases, focusing on the pathogenetic mechanisms underlying this association.

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页数：11

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