The yeast G protein α subunit Gpa1 transmits a signal through an RNA binding effector protein Scp160

被引：52

作者：

Guo, M

Aston, C

Burchett, SA

Dyke, C

Fields, S

Rajarao, SJR

Uetz, P

Wang, YQ

Young, K

Dohlman, HG ^{[1
]}

机构：

[1] Univ N Carolina, Dept Biochem & Biophys, Chapel Hill, NC 27599 USA

[2] Yale Univ, Interdepartmental Neurosci Program, New Haven, CT 06520 USA

[3] Wyeth Ayerst Res, Neurosci Res, Princeton, NJ 08543 USA

[4] NIH, Lab Neural Connect, Bethesda, MD 20892 USA

[5] Univ Washington, Dept Genome Sci & Med, Seattle, WA 98195 USA

[6] Univ Washington, Howard Hughes Med Inst, Seattle, WA 98195 USA

来源：

MOLECULAR CELL | 2003年 / 12卷 / 02期

关键词：

D O I：

10.1016/S1097-2765(03)00307-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In yeast Saccharomyces cerevisiae the G protein betagamma subunits (Ste4/Ste18) have long been known to transmit the signal required for mating. Here we demonstrate that GTPase-deficient mutants of Galpha (Gpa1) directly activate the mating response pathway. We also show that signaling by activated Gpa1 requires direct coupling to an RNA binding protein Scp160. These findings suggest an additional role for Gpa1 and reveal Scp160 as a component of the mating response pathway in yeast.

引用

页码：517 / 524

页数：8

共 36 条

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