Regulation of the cell cycle by SCF-type ubiquitin ligases

被引：297

作者：

Nakayama, KI

Nakayama, K ^{[1
]}

机构：

[1] Japan Sci & Technol Corp, CREST, Kawaguchi, Saitama 3320012, Japan

[2] Kyushu Univ, Med Inst Bioregulat, Dept Mol & Cellular Biol, Higashi Ku, Fukuoka 8128582, Japan

[3] Tohoku Univ, Sch Med, Ctr Translat & Adv Anim Res Human Dis, Div Dev Genet, Sendai, Miyagi 9808575, Japan

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2005年 / 16卷 / 03期

关键词：

cell cycle; proteolysis; ubiquitin; SCF complex; F-box protein;

D O I：

10.1016/j.semcdb.2005.02.010

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Regulation of the cell cycle is dependent on protein degradation by the ubiquitin-proteasome system. Two major ubiquitin ligases, the anaphase-promoting complex or cyclosome (APC/C) and SCF complex, are responsible for the periodic proteolysis of many regulators of the cell cycle. The receptor component of the SCF complex is one of many F-box proteins, three of which - Skp2, Fbw7, and beta-TrCP-are well characterized and implicated in cell cycle regulation. We have generated mice deficient in Skp2, Fbw7, or beta-TrCP1 and have identified the roles of these proteins in both cell cycle regulation and mouse development. Clinical evidence also suggests that dysregulation of these F-box proteins contributes to human cancers. (c) 2005 Elsevier Ltd. All rights reserved.

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收藏

页码：323 / 333

页数：11

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