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The ins and outs of nucleosome assembly

被引：118
作者：
Mello, JA [1 ]
Almouzni, G [1 ]
机构：
[1] Inst Curie, Res Sect, CNRS, UMR 218, F-75248 Paris 05, France
来源：
CURRENT OPINION IN GENETICS & DEVELOPMENT | 2001年 / 11卷 / 02期
关键词：
D O I：
10.1016/S0959-437X(00)00170-2
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
De novo nucleosome assembly coupled to DNA replication and repair in vitro involves the histone chaperone chromatin assembly factor 1 (CAF-I). Recent studies support a model in which CAF-1 can be targeted to newly synthesized DNA through a direct interaction with proliferating cell nuclear antigen (PCNA) and can act synergistically with a newly identified histone chaperone. Insights have also been obtained into mechanisms by which this CAF-1-dependent pathway can establish a repressed chromatin state.
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页码：136 / 141
页数：6
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