Migraine and the risk of stroke, TIA, or death in the UK

被引：36

作者：

Becker, Claudia

Brobert, Gunnar P.

Almqvist, Per M.

Johansson, Saga

Jick, Susan S.

Meier, Christoph R.

机构：

[1] Univ Basel Hosp, Div Clin Pharmacol & Toxicol, Basel Pharcoepidemiol Unit, CH-4031 Basel, Switzerland

[2] AstraZeneca Res & Dev, Sodertalje, Sweden

[3] AstraZeneca Res & Dev, Molndal, Sweden

[4] Gothenburg Univ, Sect Prevent Cardiol, S-41124 Gothenburg, Sweden

[5] Boston Univ, Med Ctr, Boston Collaborat Drug Surveillance Program, Lexington, MA USA

来源：

HEADACHE | 2007年 / 47卷 / 10期

关键词：

migraine; general practice research database; epidemiology; stroke; triptan;

D O I：

10.1111/j.1526-4610.2007.00937.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background.-Previous observational studies have reported a higher risk of stroke in migraine patients. Objective.-We aimed to estimate the risk of stroke, transient ischemic attack (TIA), or death in migraineurs in the UK. Method.-We conducted a population-based follow-up study within the General Practice Research Database from 1994 to 2001. Results.-The relative risk (RR) of stroke in migraineurs compared with non-migraineurs was 2.2 (95% confidence interval [CI] 1.7-2.9). It was highest for patients with a migraine diagnosis recorded within 30 days prior to a stroke (odds ratio 11.1, 95% CI 5.69-21.5). The RR of TIA in migraineurs compared with non-migraineurs was 2.4 (95% CI 1.8-3.3), the mortality of migraineurs was slightly decreased. Conclusion.-In our study, the RR of developing a stroke or a TIA was doubled in migraineurs as compared with non-migraineurs, while that for death was close to unity.

引用

收藏

页码：1374 / 1384

页数：11

相关论文

共 34 条

[1] Migraine and stroke [J].

Agostoni, E ;

Fumagalli, L ;

Santoro, P ;

Ferrarese, C .

NEUROLOGICAL SCIENCES, 2004, 25 (Suppl 3) :S123-S125

[2] MIGRAINE AND SUBSEQUENT RISK OF STROKE IN THE PHYSICIANS HEALTH STUDY [J].

BURING, JE ;

HEBERT, P ;

ROMERO, J ;

KITTROSS, A ;

COOK, N ;

MANSON, J ;

PETO, R ;

HENNEKENS, C .

ARCHIVES OF NEUROLOGY, 1995, 52 (02) :129-134

[3] History of migraine and risk of cerebral ischaemia in young adults [J].

Carolei, A ;

Marini, C ;

DeMatteis, G ;

Fieschi, C ;

Frontoni, M ;

Zanette, E ;

Inzitari, D ;

Nencini, P ;

Gandolfo, C ;

Finocchi, C ;

Prencipe, M ;

Totaro, R ;

Landi, G ;

Motto, C ;

DeZanche, L ;

Parma, M ;

Scoditti, U .

LANCET, 1996, 347 (9014) :1503-1506

[4]

Chang CL, 1999, BMJ-BRIT MED J, V318, P13

[5] A multinational investigation of the impact of subcutaneous sumatriptan .2. Health-related quality of life [J].

Dahlof, C ;

Bouchard, J ;

Cortelli, P ;

Heywood, J ;

Jansen, JP ;

Pham, S ;

Hirsch, J ;

Adams, J ;

Miller, DW .

PHARMACOECONOMICS, 1997, 11 (Suppl 1) :24-34

[6] Perfusion weighted imaging during migraine: spontaneous visual aura and headache [J].

del Rio, MS ;

Bakker, D ;

Wu, O ;

Agosti, R ;

Mitsikostas, DD ;

Ostergaard, L ;

Wells, WA ;

Rosen, BR ;

Sorensen, G ;

Moskowitz, MA ;

Cutrer, FM .

CEPHALALGIA, 1999, 19 (08) :701-707

[7] Risk of ischaemic stroke in people with migraine: systematic review and meta-analysis of observational studies [J].

Etminan, M ;

Takkouche, B ;

Isorna, FC ;

Samii, A .

BMJ-BRITISH MEDICAL JOURNAL, 2005, 330 (7482) :63-65

[8] Triptans (serotonin, 5-HT1B/1D agonists) in migraine:: detailed results and methods of a meta-analysis of 53 trials [J].

Ferrari, MD ;

Goadsby, PJ ;

Roon, KI ;

Lipton, RB .

CEPHALALGIA, 2002, 22 (08) :633-658

[9] VASOACTIVE PEPTIDE LEVELS IN THE PLASMA OF YOUNG MIGRAINE PATIENTS WITH AND WITHOUT AURA ASSESSED BOTH INTERICTALLY AND ICTALLY [J].

GALLAI, V ;

SARCHIELLI, P ;

FLORIDI, A ;

FRANCESCHINI, M ;

CODINI, M ;

GLIOTI, G ;

TREQUATTRINI, A ;

PALUMBO, R .

CEPHALALGIA, 1995, 15 (05) :384-390

[10] Diagnosis and initial management of stroke and transient ischemic attack across UK health regions from 1992 to 1996 - Experience of a national primary care database [J].

Gibbs, RGJ ;

Newson, R ;

Lawrenson, R ;

Greenhalgh, RM ;

Davies, AH .

STROKE, 2001, 32 (05) :1085-1090

← 1 2 3 4 →