Lactobacillus protects the integrity of intestinal epithelial barrier damaged by pathogenic bacteria

被引：109

作者：

Yu, Qinghua ^{[1
]}

Yuan, Lixia ^{[1
]}

Deng, Jun ^{[1
]}

Yang, Qian ^{[1
]}

机构：

[1] Nanjing Agr Univ, Coll Vet Med, Nanjing 210095, Jiangsu, Peoples R China

来源：

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY | 2015年 / 5卷

关键词：

Lactobacillus; paracellular permeability; IL-8; mucosal barrier; tight junction; ESCHERICHIA-COLI; TIGHT JUNCTIONS; CELLS; PROBIOTICS; CYTOKINES; DYSFUNCTION; INFECTION; PATHWAYS;

D O I：

10.3389/fcimb.2015.00026

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Pathogens invade intestinal mucosal barrier through phagocytosis of antigen presenting cells (dendritic cell, microfold cells), or through the invasion into the intestinal epithelial directly. Some pathogens could damage the cell junction between epithelial cells and use the paracellular pathway as an entrance to invade. Moreover, some Lactobacillus could inhibit the adhesion of the pathogens and protect the integrity of the cell junction and mucosal barrier. This research focused on the potential therapeutic effect of Lactobacillus fructosus (Lactobacillus fructosus) C2 to attenuate ETEC K88 or S. typhimurium SL1344 induced changes to mucosal barrier. The results demonstrated that treatment of polarized Caco-2 cells with Lactobacillus fructosus C2 reduced the permeation of dextran, and expression of IL-8, p-ERK, and p-JNK when cells were infected with pathogenic bacteria. The findings indicated that Lactobacillus fructosus C2 exerted a protective effect against the damage to the integrity of Caco-2 cells by ETEC or S. typhimurium infection.

引用

页数：7

共 28 条

[1]

Lactobacillus plantarum MB452 enhances the function of the intestinal barrier by increasing the expression levels of genes involved in tight junction formation [J].