Roles of HMGA proteins in cancer

被引：619

作者：

Fusco, Alfredo

Fedele, Monica

机构：

[1] Univ Naples Federico II, Fac Med & Chirurg, Dipartimento Biol & Patol Cellular Mol, I-80131 Naples, Italy

[2] CNR, Ist Endocrinol & Oncol Sperimentale, Naples, Italy

[3] Naples Oncongenom Ctr, EINGE Biotechnol Avanzate, Napoli & SEMM European Sch Mol Med, I-80145 Naples, Italy

来源：

NATURE REVIEWS CANCER | 2007年 / 7卷 / 12期

关键词：

D O I：

10.1038/nrc2271

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The high mobility group A (HMGA) non-histone chromatin proteins alter chromatin structure and thereby regulate the transcription of several genes by either enhancing or suppressing transcription factors. This protein family is implicated, through different mechanisms, in both benign and malignant neoplasias. Rearrangements of HMGA genes are a feature of most benign human mesenchymal tumours. Conversely, unrearranged HMGA overexpression is a feature of malignant tumours and is also causally related to neoplastic cell transformation. Here, we focus on the role of the HMGA proteins in human neoplastic diseases, the mechanisms by which they contribute to carcinogenesis, and therapeutic strategies based on targeting HMGA proteins.

引用

页码：899 / 910

页数：12

共 159 条

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