Taurolidine lock: The key to prevention of recurrent catheter-related bloodstream infections

被引：58

作者：

Jurewitsch, B ^{[1
]}

Jeejeebhoy, KN ^{[1
]}

机构：

[1] Univ Toronto, St Michaels Hosp, Digest Dis Program, Toronto, ON M5B 1W8, Canada

来源：

CLINICAL NUTRITION | 2005年 / 24卷 / 03期

关键词：

taurolidine; lock solution; catheter infection; bloodstream infection;

D O I：

10.1016/j.clnu.2005.02.001

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

The literature shows that repeated courses of antibiotics and catheter removals in a subset of patients suffering from multiple catheter-related bloodstream infections (CRBSI), are unlikely to prevent recurrence. In acceding to preventative strategies, we report our application of the antimicrobial chemotherapeutic Taurolidine used as a daily flush solution in seven home TPN patients suffering from multiple episodes. A pretreatment infection rate of 10.8 infections per 1000 catheter days decreased to 0.8 after treatment. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：462 / 465

页数：4

共 15 条

[1] Prophylaxis against dialysis catheter-related bacteremia with a novel antimicrobial lock solution [J].

Allon, M .

CLINICAL INFECTIOUS DISEASES, 2003, 36 (12) :1539-1544

[2]

Browne M, 1985, NEW CONCEPT ANTIMICR, P51

[3] Bacterial biofilms: A common cause of persistent infections [J].

Costerton, JW ;

Stewart, PS ;

Greenberg, EP .

SCIENCE, 1999, 284 (5418) :1318-1322

[4] REDUCED ADHERENCE OF MICROORGANISMS TO HUMAN MUCOSAL EPITHELIAL-CELLS FOLLOWING TREATMENT WITH TAUROLIN, A NOVEL ANTIMICROBIAL AGENT [J].

GORMAN, SP ;

MCCAFFERTY, DF ;

WOOLFSON, AD ;

JONES, DS .

JOURNAL OF APPLIED BACTERIOLOGY, 1987, 62 (04) :315-320

[5] THE EFFECTS OF 3 NON-ANTIBIOTIC, ANTIMICROBIAL AGENTS ON THE SURFACE HYDROPHOBICITY OF CERTAIN MICROORGANISMS EVALUATED BY DIFFERENT METHODS [J].

JONES, DS ;

GORMAN, SP ;

MCCAFFERTY, DF ;

WOOLFSON, AD .

JOURNAL OF APPLIED BACTERIOLOGY, 1991, 71 (03) :218-227

[6] Taurolidine is effective in the treatment of central venous catheter-related bloodstream infections in cancer patients [J].

Koldehoff, A ;

Zakrzewski, JL .

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2004, 24 (05) :491-495

[7] Guidelines for the prevention of intravascular catheter-related infections [J].

O'Grady, NP ;

Alexander, M ;

Dellinger, EP ;

Gerberding, JL ;

Heard, SO ;

Maki, DG ;

Masur, H ;

McCormick, RD ;

Mermel, LA ;

Pearson, ML ;

Raad, II ;

Randolph, A ;

Weinstein, RA .

CLINICAL INFECTIOUS DISEASES, 2002, 35 (11) :1281-1307

[8]

Reinmüller J, 1999, ZBL CHIR, V124, P13

[9] CONTRIBUTION OF VASCULAR CATHETER MATERIAL TO THE PATHOGENESIS OF INFECTION - THE ENHANCED RISK OF SILICONE IN-VIVO [J].

SHERERTZ, RJ ;

CARRUTH, WA ;

MAROSOK, RD ;

ESPELAND, MA ;

JOHNSON, RA ;

SOLOMON, DD .

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, 1995, 29 (05) :635-645

[10] COLONIZATION OF BACTERIA ON POLYVINYL-CHLORIDE AND TEFLON INTRAVASCULAR CATHETERS IN HOSPITALIZED-PATIENTS [J].

SHETH, NK ;

FRANSON, TR ;

ROSE, HD ;

BUCKMIRE, FLA ;

COOPER, JA ;

SOHNLE, PG .

JOURNAL OF CLINICAL MICROBIOLOGY, 1983, 18 (05) :1061-1063

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