Clues to Evolution of the SERA Multigene Family in 18 Plasmodium Species

被引：36

作者：

Arisue, Nobuko ^{[1
]}

Kawai, Satoru ^{[2
]}

Hirai, Makoto ^{[3
]}

Palacpac, Nirianne M. Q. ^{[1
]}

Jia, Mozhi ^{[1
]}

Kaneko, Akira ^{[4
,5
,6
]}

Tanabe, Kazuyuki ^{[7
]}

Horii, Toshihiro ^{[1
]}

机构：

[1] Osaka Univ, Microbial Dis Res Inst, Dept Mol Protozool, Osaka, Japan

[2] Dokkyo Univ, Sch Med, Lab Trop Med & Parasitol, Shimotsuga, Tochigi, Japan

[3] Gunma Univ, Grad Sch Med, Dept Parasitol, Gunma, Japan

[4] Osaka City Univ, Grad Sch Med, Dept Parasitol, Osaka 558, Japan

[5] Karolinska Inst, Isl Malaria Grp, Dept Microbiol Tumor & Cell Biol, Stockholm, Sweden

[6] Nagasaki Univ, Inst Trop Med, Nagasaki 852, Japan

[7] Osaka Univ, Microbial Dis Res Inst, Lab Malariol, Osaka, Japan

来源：

PLOS ONE | 2011年 / 6卷 / 03期

关键词：

SERINE-REPEAT-ANTIGEN; PHYLOGENETIC ANALYSIS; EXPRESSION PATTERNS; AOTUS MONKEYS; FALCIPARUM; MALARIA; PROTEIN; PROTEASES; SEQUENCE; ORIGIN;

D O I：

10.1371/journal.pone.0017775

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

SERA gene sequences were newly determined from 11 primate Plasmodium species including two human parasites, P. ovale and P. malariae, and the evolutionary history of SERA genes was analyzed together with 7 known species. All have one each of Group I to III cysteine-type SERA genes and varying number of Group IV serine-type SERA genes in tandem cluster. Notably, Group IV SERA genes were ascertained in all mammalian parasite lineages; and in two primate parasite lineages gene events such as duplication, truncation, fragmentation and gene loss occurred at high frequency in a manner that mimics the birth-and-death evolution model. Transcription profile of individual SERA genes varied greatly among rodent and monkey parasites. Results support the lineage-specific evolution of the Plasmodium SERA gene family. These findings provide further impetus for studies that could clarify/provide proof-of-concept that duplications of SERA genes were associated with the parasites' expansion of host range and the evolutionary conundrums of multigene families in Plasmodium.

引用

页数：12

共 48 条

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A malarial cysteine protease is necessary for Plasmodium sporozoite egress from oocysts [J].