Influenza vaccination of patients with systemic lupus erythematosus: Safety and immunogenecity issues

被引：33

作者：

Abu-Shakra, Mahmoud ^{[1
]}

Press, Joseph ^{[1
]}

Buskila, Dan ^{[1
]}

Sukenik, Shaul ^{[1
]}

机构：

[1] Ben Gurion Univ Negev, Soroka Med Ctr, Dept Med, Rheumat Dis Unit, IL-84105 Beer Sheva, Israel

来源：

AUTOIMMUNITY REVIEWS | 2007年 / 6卷 / 08期

关键词：

SLE; influenza; vaccination; autoantibodies; SLEDAI;

D O I：

10.1016/j.autrev.2006.12.004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The influenza vaccine is highly efficacious in the general population; however there have been concerns about the safety, and immunogenecity of the vaccine in patients with SLE. Several studies have suggested that the immune response of patients with SLE to influenza vaccine is significantly lower than the general population, mainly in patients with age a 50 years and those treated with prednisone. The vaccine is safe for patients with SLE and it does not affect the clinical manifestations of SLE including renal features, disease activity, or the requirement for steroids or cytotoxic drugs. However, the vaccine may trigger the generation of autoantibodies which is usually short term and is not associated with clinical significance. (c) 2007 Elsevier B.V. All rights reserved.

引用

页码：543 / 546

页数：4

共 20 条

[1]

Abu-Shakra M, 2002, J RHEUMATOL, V29, P2555

[2] Influenza virus vaccination of patients with SLE: Effects on generation of autoantibodies [J].