In vitro absorption and metabolism of nobiletin, a chemopreventive polymethoxyflavonoid in citrus fruits

被引：60

作者：

Murakami, A

Kuwahara, S

Takahashi, Y

Ito, C

Furukawa, H

Ju-Ichi, M

Koshimizu, K

Ohigashi, H ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Agr, Div Appl Life Sci, Kyoto 6068502, Japan

[2] Kinki Univ, Fac Biol Oriented Sci & Technol, Dept Biotechnol Sci, Wakayama 6496493, Japan

[3] Wakayama Agr Proc Res Corp, Div Res & Dev, Momoyama, Wakayama 6496112, Japan

[4] Meijo Univ, Fac Pharm, Tempa Ku, Nagoya, Aichi 4688503, Japan

[5] Mukogawa Womens Univ, Fac Pharmaceut Sci, Nishinomiya, Hyogo 6638179, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2001年 / 65卷 / 01期

关键词：

nobiletin; luteolin; metabolism; rat liver S-9 mixture; Caco-2; cells;

D O I：

10.1271/bbb.65.194

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

The polymethoxyflavonoid (PMF), nobiletin (NOB), specifically occurs in citrus fruits, and is currently believed to be a promising anti-inflammatory and antitumor promoting agent, In the present study, we investigated the in vitro absorption and metabolism of NOB and compared them with those of the polyhydroxyflavonoid (PHF), luteolin (LT), NOB preferentially accumulated in a differentiated Caco-2 cell monolayer, which is a model for small intestinal epithelial cells, while LT did not, Treatment of NOB with a rat liver S-9 mixture led to the formation of 3'-demethyl-NOB, while that of LT did not, We thus suggest that PMFs including NOB have properties distinct from those of general flavonoids for absorption and metabolism in vitro.

引用

页码：194 / 197

页数：4

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[3]

Two new polymethoxylated flavones, a class of compounds with potential anticancer activity, isolated from cold pressed Dancy tangerine peel oil solids [J].