Keeping quiet: microRNAs in HIV-1 latency

被引：27

作者：

Han, Yefei ^{[1
]}

Siliciano, Robert F. ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Baltimore, MD 21205 USA

来源：

NATURE MEDICINE | 2007年 / 13卷 / 10期

关键词：

D O I：

10.1038/nm1007-1138

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

MicroRNAs contribute to HIV- 1 latency in resting T cells. This finding could potentially be used in the development of therapies targeted to purge the latent reservoir in an effort to clear the body of virus ( pages 1241 - 1247).

引用

页码：1138 / 1140

页数：4

共 12 条

[1] Is RNA interference involved in intrinsic antiviral immunity in mammals? [J].

Cullen, Bryan R. .

NATURE IMMUNOLOGY, 2006, 7 (06) :563-567

[2] Beginning to understand microRNA function [J].

Du, Tingting ;

Zamore, Phillip D. .

CELL RESEARCH, 2007, 17 (08) :661-663

[3] Experimental approaches to the study of HIV-1 latency [J].

Han, Yefei ;

Wind-Rotolo, Megan ;

Yang, Hung-Chih ;

Siliciano, Janet D. ;

Siliciano, Robert F. .

NATURE REVIEWS MICROBIOLOGY, 2007, 5 (02) :95-106

[4] Cellular microRNAs contribute to HIV-1 latency in resting primary CD4+ T lymphocytes [J].

Huang, Jialing ;

Wang, Fengxiang ;

Argyris, Elias ;

Chen, Keyang ;

Liang, Zhihui ;

Tian, Heng ;

Huang, Wenlin ;

Squires, Kathleen ;

Verlinghieri, Gwen ;

Zhang, Hui .

NATURE MEDICINE, 2007, 13 (10) :1241-1247

[5] Modulation of hepatitis C virus RNA abundance by a liver-specific microRNA [J].

Jopling, CL ;

Yi, MK ;

Lancaster, AM ;

Lemon, SM ;

Sarnow, P .

SCIENCE, 2005, 309 (5740) :1577-1581

[6] The multifactorial nature of HIV-1 latency [J].

Lassen, K ;

Han, YF ;

Zhou, Y ;

Siliciano, J ;

Siliciano, RF .

TRENDS IN MOLECULAR MEDICINE, 2004, 10 (11) :525-531

[7] A cellular MicroRNA mediates antiviral defense in human cells [J].

Lecellier, CH ;

Dunoyer, P ;

Arar, K ;

Lehmann-Che, J ;

Eyquem, S ;

Himber, C ;

Saïb, A ;

Voinnet, O .

SCIENCE, 2005, 308 (5721) :557-560

[8] Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets [J].

Lewis, BP ;

Burge, CB ;

Bartel, DP .

CELL, 2005, 120 (01) :15-20

[9] Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection [J].

Palella, FJ ;

Delaney, KM ;

Moorman, AC ;

Loveless, MO ;

Fuhrer, J ;

Satten, GA ;

Aschman, DJ ;

Holmberg, SD .

NEW ENGLAND JOURNAL OF MEDICINE, 1998, 338 (13) :853-860

[10]

PETERSON S, 2007, ADV PHARM HIV 1 MOL, P411

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