Molecular Classification of Low-Grade Diffuse Gliomas

被引：191

作者：

Kim, Young Ho

Nobusawa, Sumihito ^{[7
]}

Mittelbronn, Michel ^{[2
]}

Paulus, Werner ^{[3
]}

Brokinkel, Benjamin ^{[4
]}

Keyvani, Kathy ^{[5
]}

Sure, Ulrich ^{[6
]}

Wrede, Karsten ^{[6
]}

Nakazato, Yoichi ^{[7
]}

Tanaka, Yuko ^{[7
]}

Vital, Anne ^{[8
]}

Mariani, Luigi ^{[9
]}

Stawski, Robert

Watanabe, Takuya

De Girolami, Umberto ^{[10
,11
]}

Kleihues, Paul ^{[12
]}

Ohgaki, Hiroko ^{[1
]}

机构：

[1] Int Agcy Res Canc, Sect Mol Pathol, 150 Cours Albert Thomas, F-69372 Lyon 08, France

[2] Neurosci Ctr Frankfurt, Dept Neuropathol, Frankfurt, Germany

[3] Univ Hosp Munster, Inst Neuropathol, Munster, Germany

[4] Univ Hosp Munster, Dept Neurosurg, Munster, Germany

[5] Univ Hosp Essen, Inst Pathol & Neuropathol, Essen, Germany

[6] Univ Hosp Essen, Dept Neurosurg, Essen, Germany

[7] Gunma Univ, Dept Pathol, Gunma, Japan

[8] CNRS, Bordeaux Inst Neurosci, UMR 5227, Bordeaux, France

[9] Univ Basel, Univ Hosp, Basel, Switzerland

[10] Brigham & Womens Hosp, Boston, MA 02115 USA

[11] Univ Hosp, Dept Neuropathol, Zurich, Switzerland

[12] Univ Hosp, Dept Pathol, Zurich, Switzerland

来源：

AMERICAN JOURNAL OF PATHOLOGY | 2010年 / 177卷 / 06期

关键词：

CODON; 132; MUTATION; IDH1; MUTATIONS; EUROPEAN ORGANIZATION; GENETIC ALTERATIONS; TP53; SURVIVAL RATES; 1P/19Q LOSS; ASTROCYTOMAS; OLIGODENDROGLIOMA; TUMORS;

D O I：

10.2353/ajpath.2010.100680

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

The current World Health Organization classification recognizes three histological types of grade H low grade diffuse glioma (diffuse astrocytoma oligoastrocytoma and oligodendroglioma) However the diagnostic criteria m particular for oligoastrocytoma are highly subjective The aim of our study was to establish genetic profiles for diffuse gliomas and to estimate their predictive impact In this study we screened 360 World Health Organization grade II gliomas for mutations in the IDH1 IDH2 and TP53 genes and for 1p/19q loss and correlated these with clinical outcome Most tumors (86%) were characterized genetically by 77353 mutation plus IDH1/2 muta non (32%) 1p/19q loss plus IDH1/2 mutation (37%) or IDH1/2 mutation only (17%) TP53 mutations only or 1p/19q loss only was rare (2 and 3% respectively) The median survival of patients with TP53 mutation +/- IDH1/2 mutation was significantly shorter than that of patients with 1p/19q loss +/- IDH1/2 mutation (51 8 months vs 587 months respectively P = 0 0037) Multivariate analysis with adjustment for age and treatment confirmed these results (P = 0 0087) and also revealed that TP53 mutation is a significant prognostic marker for shorter survival (P = 0 0005) and 1p/19q loss for longer survival (P = 0 0002) while IDH1/2 mutations are not prognostic (P = 0 8737) The molecular classification on the basis of IDH1/2 mutation TP53 mutation and 1p/19q loss has power similar to histological classification and avoids the ambiguity inherent to the diagnosis of oligoastrocytoma. (Am J Pathol 2010 177 2708-2714 DOI 10 2353/ajpath 2010 100680)

引用

页码：2708 / 2714

页数：7

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