A galactopyranose analogue of hydantocidin

被引：30

作者：

Brandstetter, TW

Wormald, MR

Dwek, RA

Butters, TD

Platt, FM

Tsitsanou, KE

Zographos, SE

Oikonomakos, NG

Fleet, GWJ

机构：

[1] UNIV OXFORD,DEPT BIOCHEM,INST GLYCOBIOL,OXFORD OX1 3QU,ENGLAND

[2] NATL HELLEN RES FDN,GR-11635 ATHENS,GREECE

来源：

TETRAHEDRON-ASYMMETRY | 1996年 / 7卷 / 01期

关键词：

D O I：

10.1016/0957-4166(95)00432-7

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The synthesis of (2R,3R,4S,5R,6S)-3,4,5-trihydroxy-2-hydroxymethyl-7,9-diaza-oxaspiro-[4,5]decane-8,10-dione, a galactopyranose analogue of the powerful herbicide hydantocidin, is described. The compound caused no inhibition of the activity of a number of glucosyl or galactosyl transferases, or of alpha- or beta-galactosidases. An azidoester containing a galactopyranosyl moiety may be a useful intermediate for the generation of libraries of compounds of galactose mimics.

引用

页码：157 / 170

页数：14

共 43 条

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