Liver Transplantation for Alcoholic Liver Disease

被引:62
作者
Addolorato, Giovanni [1 ]
Bataller, Ramon [2 ,3 ]
Burra, Patrizia [4 ]
DiMartini, Andrea [5 ]
Graziadei, Ivo [6 ,7 ,8 ]
Lucey, Michael R. [9 ]
Mathurin, Philippe [10 ]
O'Grady, John [11 ]
Pageaux, Georges [12 ]
Berenguer, Marina [13 ,14 ,15 ]
机构
[1] Univ Cattolica Sacro Cuore, Dept Internal Med Gastroenterol & Hepatol, Alcohol Use Disorders Unit, Rome, Italy
[2] Univ N Carolina, Div Gastroenterol & Hepatol, Ctr Liver, Dept Med, Chapel Hill, NC USA
[3] Univ N Carolina, Div Gastroenterol & Hepatol, Ctr Liver, Dept Nutr, Chapel Hill, NC USA
[4] Padova Univ Hosp, Multivisceral Transplant Unit, Gastroenterol Dept Surg Oncol & Gastroenterol, Padua, Italy
[5] Univ Pittsburgh, Med Ctr, Starzl Transplant Inst, Pittsburgh, PA USA
[6] Med Univ Innsbruck, Dept Internal Med 2, A-6020 Innsbruck, Austria
[7] Acad Teaching Hosp Hall, Innsbruck, Austria
[8] Acad Teaching Hosp Hall, Dept Internal Med, Innsbruck, Austria
[9] Univ Wisconsin, Sch Med & Publ Hlth, Dept Med, Div Gastroenterol & Hepatol, Madison, WI 53706 USA
[10] Ctr Hosp Reg & Univ Lille, Hop Huriez, Serv Malad Appareil Digestif, Pl Verdun, F-59037 Lille, France
[11] Kings Coll Hosp London, Liver Unit, Denmark Hill, London, England
[12] Univ Montpellier, CHU St Eloi, Dept Hepatogastroenterol & Transplantat, F-34059 Montpellier, France
[13] Ciberehd, La Fe Univ Hosp, Liver Transplantat & Hepatol Unit, Valencia, Spain
[14] Univ Valencia, Valencia, Spain
[15] Univ Valencia, Ciberehd, Valencia, Spain
关键词
DE-NOVO MALIGNANCIES; SUBSTANCE USE; RISK-FACTORS; HEPATITIS; MANAGEMENT; SURVIVAL; RELAPSE; CIRRHOSIS; IMPACT; METAANALYSIS;
D O I
10.1097/TP.0000000000001156
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
071005 [微生物学]; 100108 [医学免疫学];
摘要
Alcohol-related liver disease is the second most frequent indication for liver transplantation (LT), yet as many as 90% to 95% of patients with alcohol-related end-stage liver disease are never formally evaluated for LT. Furthermore, despite its significance as a cause of chronic liver disease and indication for LT, it has received little attention in recent years for several reasons, including the good posttransplant short-term results, and the lack of specific "drugs" used for this disease. A writing group, endorsed by the International Liver Transplant Society, was convened to write guidelines on Liver Transplantation for Alcoholic Liver Disease to summarize current knowledge and provide answers to controversial and delicate ethical as well as clinical problems. We report here a short version of the guidelines (long version available at www.ilts.org) with the final recommendations graded for level of evidence. The writing group membership is expected to remain active for 5 years, reviewing the guideline annually, and updating the online version when appropriate.
引用
收藏
页码:981 / 987
页数:7
相关论文
共 46 条
[1]
Effectiveness and safety of baclofen for maintenance of alcohol abstinence in alcohol-dependent patients with liver cirrhosis: randomised, double-blind controlled study [J].
Addolorato, Giovanni ;
Leggio, Lorenzo ;
Ferrulli, Anna ;
Cardone, Silvia ;
Vonghia, Luisa ;
Mirijello, Antonio ;
Abenavoli, Ludovico ;
D'Angelo, Cristina ;
Caputo, Fabio ;
Zambon, Antonella ;
Haber, Paul S. ;
Gasbarrini, Giovanni .
LANCET, 2007, 370 (9603) :1915-1922
[2]
Liver Transplantation in Alcoholic Patients: Impact of an Alcohol Addiction Unit Within a Liver Transplant Center [J].
Addolorato, Giovanni ;
Mirijello, Antonio ;
Leggio, Lorenzo ;
Ferrulli, Anna ;
D'Angelo, Cristina ;
Vassallo, Gabriele ;
Cossari, Anthony ;
Gasbarrini, Giovanni ;
Landolfi, Raffaele ;
Agnes, Salvatore ;
Gasbarrini, Antonio .
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 2013, 37 (09) :1601-1608
[3]
Naltrexone for the management of alcohol dependence [J].
Anton, Raymond F. .
NEW ENGLAND JOURNAL OF MEDICINE, 2008, 359 (07) :715-721
[4]
General compliance after liver transplantation for alcoholic cirrhosis [J].
Berlakovich, GA ;
Langer, F ;
Freundorfer, E ;
Windhager, T ;
Rockenschaub, S ;
Sporn, E ;
Soliman, T ;
Pokorny, H ;
Steininger, R ;
Mühlbacher, F .
TRANSPLANT INTERNATIONAL, 2000, 13 (02) :129-135
[5]
Liver Transplantation for Alcoholic Liver Disease in Europe: A Study from the ELTR (European Liver Transplant Registry) [J].
Burra, P. ;
Senzolo, M. ;
Adam, R. ;
Delvart, V. ;
Karam, V. ;
Germani, G. ;
Neuberger, J. .
AMERICAN JOURNAL OF TRANSPLANTATION, 2010, 10 (01) :138-148
[6]
Alcohol recidivism impairs long-term patient survival after orthotopic liver transplantation for alcoholic liver disease [J].
Cuadrado, A ;
Fábrega, E ;
Casafont, F ;
Pons-Romero, F .
LIVER TRANSPLANTATION, 2005, 11 (04) :420-426
[7]
Detecting Lifetime Alcohol Problems in Individuals Referred for Liver Transplantation for Nonalcoholic Liver Failure [J].
Day, Ed ;
Best, David ;
Sweeting, Ruth ;
Russell, Rebecca ;
Webb, Kerry ;
Georgiou, George ;
Neuberger, James .
LIVER TRANSPLANTATION, 2008, 14 (11) :1609-1613
[8]
A simple score for predicting alcohol relapse after liver transplantation - Results from 387 patients over 15 years [J].
De Gottardi, Andrea ;
Spahr, Laurent ;
Gelez, Pascale ;
Morard, Isabelle ;
Mentha, Gilles ;
Guillaud, Olivier ;
Majno, Pietro ;
Morel, Philippe ;
Hadengue, Antoine ;
Paliard, Pierre ;
Scoazec, Jean-Yves ;
Boillot, Olivier ;
Giostra, Emile ;
Dumortier, Jerome .
ARCHIVES OF INTERNAL MEDICINE, 2007, 167 (11) :1183-1188
[9]
Cardiovascular risk factors following orthotopic liver transplantation: predisposing factors, incidence and management [J].
Desai, Shireena ;
Hong, Johnny C. ;
Saab, Sammy .
LIVER INTERNATIONAL, 2010, 30 (07) :948-957
[10]
Meta-analysis of risk for relapse to substance use after transplantation of the liver or other solid organs [J].
Dew, Mary Amanda ;
DiMartini, Andrea F. ;
Steel, Jennifer ;
Dabbs, Annette De Vito ;
Myaskovsky, Larissa ;
Unruh, Mark ;
Greenhouse, Joel .
LIVER TRANSPLANTATION, 2008, 14 (02) :159-172