Aberrant caveolin-1 expression in psoriasis: A signalling hypothesis

被引：9

作者：

Campbell, L ^{[1
]}

Gumbleton, M ^{[1
]}

机构：

[1] Cardiff Univ, Welsh Sch Pharm, Pharmaceut Cell Biol Res Grp, Cardiff CF10 3XF, S Glam, Wales

来源：

IUBMB LIFE | 2000年 / 50卷 / 06期

关键词：

caveolae; caveolin; cell signalling; psoriasis; skin;

D O I：

10.1080/152165400300089376

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A preliminary retrospective immunocytochemical study was conducted examining the expression of caveolin-1 in skin biopsies resected from clinically defined psoriatic subjects. These pilot investigations revealed a dramatic down-regulation of caveolin-1 (a protein product of the caveolin supergene family known to regulate signal transduction events and cell cycle dynamics) in the hyperproliferative basal regions of the epidermis in all psoriatic biopsies examined when compared to normal control samples. These results lead us to hypothesise that caveolin-1 negatively regulates key signal transduction pathways in epidermal keratinocytes and through it's reduced expression in psoriasis, pertubations in keratinocyte cell signalling and abnormal cell differentiation ensue, events fundamental to the development of the psoriatic phenotype. Novel therapeutic strategies for the treatment of psoriasis based upon caveolin-1 protein can be envisaged.

引用

页码：361 / 364

页数：4

共 17 条

[1] Inhibitors of tyrosine kinases in the treatment of psoriasis
Ben-Bassat, H
Klein, BY
[J]. CURRENT PHARMACEUTICAL DESIGN, 2000, 6 (09) : 933 - 942
[2] Levels of endothelial cell stimulating angiogenesis factor and vascular endothelial growth factor are elevated in psoriasis
Bhushan, M
McLaughlin, B
Weiss, JB
Griffiths, CEM
[J]. BRITISH JOURNAL OF DERMATOLOGY, 1999, 141 (06) : 1054 - 1060
[3] Interaction of a receptor tyrosine kinase, EGF-R, with caveolins - Caveolin binding negatively regulates tyrosine and serine/threonine kinase activities
Couet, J
Sargiacomo, M
Lisanti, MP
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (48) : 30429 - 30438
[4] Identification of peptide and protein ligands for the caveolin-scaffolding domain - Implications for the interaction of caveolin with caveolae-associated proteins
Couet, J
Li, SW
Okamoto, T
Ikezu, T
Lisanti, MP
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (10) : 6525 - 6533
[5] MAP kinase abnormalities in hyerproliferative cultured fibroblasts from psoriatic skin
Dimon-Gadal, S
Raynaud, F
Evain-Brion, D
Keryer, G
[J]. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1998, 110 (06) : 872 - 879
[6] Targeted downregulation of caveolin-1 is sufficient to drive cell transformation and hyperactivate the p42/44 MAP kinase cascade
Galbiati, F
Volonté, D
Engelman, JA
Watanabe, G
Burk, R
Pestell, RG
Lisanti, MP
[J]. EMBO JOURNAL, 1998, 17 (22) : 6633 - 6648
[7] GUMBLETON M, 2000, PHARMACEUT RES, V9, P1
[8] Calcium signal transduction from caveolae
Isshiki, M
Anderson, RGW
[J]. CELL CALCIUM, 1999, 26 (05) : 201 - 208
[9] Psoriasis and altered calcium metabolism:: Downregulated capacitative calcium influx and defective calcium-mediated cell signaling in cultured psoriatic keratinocytes
Karvonen, SL
Korkiamäki, T
Ylä-Outinen, H
Nissinen, M
Teerikangas, H
Pummi, K
Karvonen, J
Peltonen, J
[J]. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2000, 114 (04) : 693 - 700
[10] Increased activation of Ras in psoriatic lesions
Lin, PP
Baldassare, JJ
Voorhees, JJ
Fisher, GJ
[J]. SKIN PHARMACOLOGY AND APPLIED SKIN PHYSIOLOGY, 1999, 12 (1-2): : 90 - 97

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