Mutational analysis of the PTEN/MMAC1 gene in non-Hodgkin's lymphoma

被引：45

作者：

Nakahara, Y ^{[1
]}

Nagai, H ^{[1
]}

Kinoshita, T ^{[1
]}

Uchida, T ^{[1
]}

Hatano, S ^{[1
]}

Murate, T ^{[1
]}

Saito, H ^{[1
]}

机构：

[1] Nagoya Univ, Sch Med, Dept Internal Med 1, Showa Ku, Nagoya, Aichi 466, Japan

来源：

LEUKEMIA | 1998年 / 12卷 / 08期

关键词：

PTEN/MMAC1; gene; mutation; chromosome; 10q23.3; non-Hodgkin's lymphoma; phosphatase;

D O I：

10.1038/sj.leu.2401099

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The PTEN/MMAC1 gene at 10q23.3, which has dual specific phosphatase activity, is a novel tumor suppressor gene candidate. Various kinds of tumors have mutations in this gene, including glioblastoma, endometrial carcinoma and prostate cancer. We examined 29 cases of primary non-Hodgkin's lymphoma (NHL) for mutations in the PTEN/MMAC1 gene. One case of diffuse large B cell lymphoma had an 11 bp deletion, but the remaining 28 cases showed no mutations in the genome. Two of these 28 cases showed missense mutations in the PTEN/MMAC1 transcripts, but no alterations in the genomic DNA. These mRNA missense variants are similar to PTEN/MMAC1 transcript aberrations which have been reported in patients with breast cancer. These findings suggest that alterations in the PTEN/MMAC1 gene play a role in the pathogenesis of NHL.

引用

页码：1277 / 1280

页数：4

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