A locus affecting obesity in human chromosome region 10p12

被引：49

作者：

Price, RA ^{[1
]}

Li, WD ^{[1
]}

Bernstein, A ^{[1
]}

Crystal, A ^{[1
]}

Golding, EM ^{[1
]}

Weisberg, SJ ^{[1
]}

Zuckerman, WA ^{[1
]}

机构：

[1] Univ Penn, Ctr Neurobiol & Behav, Philadelphia, PA 19104 USA

来源：

DIABETOLOGIA | 2001年 / 44卷 / 03期

关键词：

obesity; genetics; linkage; body mass index; chromosome; 10; complex trait; African-American; European-American;

D O I：

10.1007/s001250051627

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aims/hypothesis. Obesity is a complex trait influenced by multiple genes. We evaluated linkage in three regions of human chromosome 10 previously linked to obesity-related phenotypes. Methods. We conducted non-parametric linkage analysis of obesity-related phenotypes in cohorts of 170 European-American and 43 African-American families having extremely obese and normal weight subjects. Results. We found support for linkage of an obesity phenotype (BMI greater than or equal to 27 kg/m(2)) in both cohorts, as well as in a combined analysis (European-American cohort, Z = 1.90, p = 0.03; African-American cohort, Z = 2.25, p = 0.014; combined cohort, Z = 2.55, p = 0.005). Conclusion/interpretation. These results confirm previous reports of linkage in French and German families. The consistency of results across these four cohorts supports the localization of a quantitative trait locus influencing obesity to human chromosome region 10p12.

引用

页码：363 / 366

页数：4

共 10 条

[1] The human obesity gene map:: The 1999 update [J].

Chagnon, YC ;

Pérusse, L ;

Weisnagel, SJ ;

Rankinen, T ;

Bouchard, C .

OBESITY RESEARCH, 2000, 8 (01) :89-117

[2] A genome-wide scan for human obesity genes reveals a major susceptibility locus on chromosome 10 [J].

Hager, J ;

Dina, C ;

Francke, S ;

Dubois, S ;

Houari, M ;

Vatin, V ;

Vaillant, E ;

Lorentz, N ;

Basdevant, A ;

Clement, K ;

Guy-Grand, B ;

Froguel, P .

NATURE GENETICS, 1998, 20 (03) :304-308

[3] Independent confirmation of a major locus for obesity on chromosome 10 [J].

Hinney, A ;

Ziegler, A ;

Oeffner, F ;

Wedewardt, C ;

Vogel, M ;

Wulftange, H ;

Geller, F ;

Stübing, K ;

Siegfried, W ;

Goldschmidt, HP ;

Remschmidt, H ;

Hebebrand, J .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2000, 85 (08) :2962-2965

[4]

Kruglyak L, 1996, AM J HUM GENET, V58, P1347

[5]

KRUGLYAK L, 1995, AM J HUM GENET, V57, P439

[6] GENETIC DISSECTION OF COMPLEX TRAITS - GUIDELINES FOR INTERPRETING AND REPORTING LINKAGE RESULTS [J].

LANDER, E ;

KRUGLYAK, L .

NATURE GENETICS, 1995, 11 (03) :241-247

[7] Genome scan for human obesity and linkage to markers in 20q13 [J].

Lee, JH ;

Reed, DR ;

Li, WD ;

Xu, WZ ;

Joo, EJ ;

Kilker, RL ;

Nanthakumar, E ;

North, M ;

Sukul, H ;

Bell, C ;

Price, RA .

AMERICAN JOURNAL OF HUMAN GENETICS, 1999, 64 (01) :196-209

[8]

OTT J, 1992, AM J HUM GENET, V51, P283

[9] Obesity related phenotypes in families selected for extreme obesity and leanness [J].

Price, RA ;

Reed, DR ;

Lee, JH .

INTERNATIONAL JOURNAL OF OBESITY, 1998, 22 (05) :406-413

[10] STATISTICAL VALIDITY OF THE HASEMAN-ELSTON SIB-PAIR TEST IN SMALL SAMPLES [J].

WILSON, AF ;

ELSTON, RC .

GENETIC EPIDEMIOLOGY, 1993, 10 (06) :593-598

← 1 →