IGFBP-3 and apoptosis -: a licence to kill?

被引：63

作者：

Butt, AJ ^{[1
]}

Williams, AC

机构：

[1] Univ Sydney, Royal N Shore Hosp, Kolling Inst Med Res, St Leonards, NSW 2065, Australia

[2] Univ Bristol, Dept Pathol & Microbiol, Canc Res Campaign Colorectal Tumour Biol Res Grp, Bristol, Avon, England

来源：

APOPTOSIS | 2001年 / 6卷 / 03期

关键词：

apoptosis; IGF; IGFBP-3; p53;

D O I：

10.1023/A:1011388710719

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Insulin-like growth factor binding protein (IGFBP)-3, the major carrier of insulin-like growth factors (IGFs) in the circulation, was first isolated and characterised over a decade ago. More recently, IGFBP-3 has been assigned a role as a putative death-promoting factor, a function that appears, under certain circumstances, to be independent of its IGF-binding ability. This review examines the current evidence for a pro-apoptotic function for IGFBP-3 and speculates on its physiological significance.

引用

页码：199 / 205

页数：7

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