Comparative study of flavonoids in experimental models of inflammation

被引：272

作者：

Rotelli, AE ^{[1
]}

Guardia, T ^{[1
]}

Juárez, AO ^{[1
]}

de la Rocha, NE ^{[1
]}

Pelzer, LE ^{[1
]}

机构：

[1] Univ Nacl San Luis, Fac Quim Bioquim & Farm, Catedra Farmacol, RA-5700 San Luis, Argentina

来源：

PHARMACOLOGICAL RESEARCH | 2003年 / 48卷 / 06期

关键词：

flavonoids; anti-inflammatory activity; animal inflammation models; adjuvant arthritis;

D O I：

10.1016/S1043-6618(03)00225-1

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The anti-inflammatory activities of flavonols (quercetin, rutin and morin) and flavanones (hesperetin and hesperidin) were investigated in animal models of acute and chronic inflammation. Rutin was only effective in the chronic process, principally in adjuvant arthritis. On neurogenic inflammation induced by xylene, only the flavanones were effective; besides, these compounds were the most effective on subchronic process. The most important compound in reducing paw oedema induced by carrageenan was quercetin. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：601 / 606

页数：6

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