Studies on reactions of pyrimidine compounds. 2. Microwave-assisted synthesis of 1,2,3,4-tetrahydro-2-thioxopyrimidine derivatives

被引：18

作者：

Aklbas, Esvet ^{[1
]}

Aslanoglu, Furgan ^{[1
]}

机构：

[1] Yuzuncu Yil Univ, Fac Arts & Sci, Dept Chem, TR-65080 Kampus, Van, Turkey

来源：

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 2008年 / 183卷 / 01期

关键词：

microwave-assisted; Biginelli reaction; thioxopyrimidine; synthesis; cyclocondensation; multicomponent reaction;

D O I：

10.1080/10426500701557021

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The 5-benzoyl-4,6-diphenyl-1,2,3,4-tetrahydro-2-thioxopyrimidine (la) and 5-benzoyl-4-(2-chlorophenyl)-6-phenyl-1,2,3,4-tetrahydro-2-thioxopyrimidine (1b) were synthesized using the Biginelli three-component cyclocondensation reaction of a beta-diketone, arylaldehyde, and thiourea under microwave irradiation. Thiazolopyrimidine (2), (3) and pyrimido[2,3-b]thiazine (4) derivatives were obtained by a Simple one-pot condensation reaction of starting compound 1b and 2-bromopropionic acid, bromoacetic acid and 3-bromopropionic acid, respectively. These reactions performed under microwave irradiation and conventional conditions. That study is suggested a simple anal efficient route for the preparation of 1,2,3,4-tetrahydro-2-thioxopyrimidine and derivatives.

引用

页码：82 / 89

页数：8

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