Colloidal polyelectrolyte complexes of chitosan and dextran sulfate towards versatile nanocarriers of bioactive molecules

Nanomedicine is an emerging field and requires new tools to achieve its goals, such as nanomaterials capable of performing various functions as bioactive (macro)molecule delivery in a spatio- and time-controlled manner, biofeedback as for instance imaging the course of a therapeutic treatment, active and controlled interaction with the biological environment as in vaccine applications. Obviously, these nanomaterials should be non-toxic, biocompatible, bioresorbable, which means also that the materials and the manufacturing processes should meet these requirements. This review is focused on colloidal polyelectrolyte complexes of chitosan and dextran sulfate, (i) because these polysaccharides comply with the above specifications; (ii) because chitosan is a complex polysaccharide whose physicochemical properties depend on the molar mass and the fraction of N-acetyl glucosamine moieties within the chain; (iii) to underline the impact of the physicochemical properties of chitosan on the performances of the colloidal complexes; (iv) to establish the versatility of the coarcervation, a mild, energy-sparing, environment friendly, straightforward to set-up manufacturing process. (C) 2010 Elsevier B.V. All rights reserved.