Metallothionein expression by NG2 glial cells following CNS injury

被引：13

作者：

Chung, R. S. ^{[1
]}

Fung, S. J. ^{[1
]}

Leung, Y. K. ^{[1
]}

Walker, A. K. ^{[1
]}

McCormack, G. H. ^{[1
]}

Chuah, M. I. ^{[1
]}

Vickers, J. C. ^{[1
]}

West, A. K. ^{[1
]}

机构：

[1] Univ Tasmania, NeuroRepair Grp, Menzies Res Inst, Hobart, Tas 7001, Australia

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2007年 / 64卷 / 19-20期

基金：

英国医学研究理事会; 澳大利亚研究理事会;

关键词：

traumatic brain injury; reactive glia; axon regeneration; inhibitory molecules;

D O I：

10.1007/s00018-007-7267-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Metallothionein (MT) expression is rapidly up-regulated following CNS injury, and there is a strong correlation between the presence or absence of MTand improved or impaired (respectively) recovery from such trauma.We now report that a distinct subset of NG2-positive, GFAP-negative glial cells bordering the injury tract express MT following focal injury to the adult rat neocortex. To confirm the ability of these NG2 glial cells to express MT, we have isolated and cultured them and identified that they can express MT following stimulation with zinc. To investigate the functional importance of MT expression by NG2 glial cells, we plated cortical neurons onto these cells and found that expression of MT enhanced the permissivity of NG2 glial cells to neurite outgrowth. Our data suggest that expression of MT by NG2 glial cells may contribute to the overall permissiveness of these cells to axon regeneration.

引用

页码：2716 / 2722

页数：7

共 29 条

[1]

NG2 proteoglycan-expressing cells of the adult rat brain: Possible involvement in the formation of glial scar astrocytes following stab wound [J].