Smad4 mediates malignant behaviors of human ovarian carcinoma cell through the effect on expressions of E-cadherin, plasminogen activator inhibitor-1 and VEGF

被引：25

作者：

Chen, Chen ^{[1
,2
]}

Sun, Ming-Zhon ^{[1
]}

Liu, Shuqing ^{[1
]}

Yeh, Dongmei ^{[1
,2
]}

Yu, Lijun ^{[1
]}

Song, Yang ^{[1
]}

Gong, Linlin ^{[1
]}

Hao, Lihong ^{[1
]}

Hu, Jun ^{[1
]}

Shao, Shujuan ^{[1
]}

机构：

[1] Dalian Med Univ, Key Lab Prote Liaoning Prov, Dalian 116044, Peoples R China

[2] Dalian Univ, Dept Anat, Dalian 116044, Peoples R China

来源：

BMB REPORTS | 2010年 / 43卷 / 08期

基金：

中国国家自然科学基金;

关键词：

Invasion; Ovarian cancer; Progression; Smad4; Tumor metastasis; UROKINASE RECEPTOR; CANCER; METASTASIS; APOPTOSIS; PATTERNS; ADHESION; INVASION; GENE;

D O I：

10.5483/BMBRep.2010.43.8.554

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Smad4 is involved in cancer progression and metastasis. Using a pair of human syngeneic epithelial ovarian cancer cells with low (HO-8910) and high (HO-8910PM) metastatic abilities, we aimed to reveal the role of Smad4 in ovarian cancer metastasis in vitro. Smad4 was down-regulated in HO-8910PM cell line relative to HO-8910 by implicating Smad4 was probably a potential tumor suppressor gene for ovarian cancer. Re-expression of Smad4 decreased the migration ability and inhibited the invasion capacity of HO-8910PM, while promoted the cell adhesion capacity for HO-8910PM. The stable expression of Smad4 increased the expression of E-cadherin, reduced the expression of plasminogen activator inhibitor-1 (PAI-1) and slightly down-regulated the expression of VEGF. Smad4 suppresses human ovarian cancer cell metastasis potential through its effect on the expressions of PAI-1, E-cadherin and VEGF. Results from current work implicate Smad4 might suppress the invasion and metastasis of human ovarian tumor cells through a TGF-beta/Smad-mediated pathway. [BMB reports 2010; 43(8): 554-560]

引用

页码：554 / 560

页数：7

共 30 条

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