HIV swiftly guts the immune system

被引:67
作者
Veazey, RS [1 ]
Lackner, AA [1 ]
机构
[1] Tulane Univ, Sch Med, Tulane Natl Primate Res Ctr, Covington, LA 70433 USA
关键词
D O I
10.1038/nm0505-469
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Two studies show that SIV directly kills massive numbers of immune cells in the gut within days of infection. The results come on the heels of similarly dramatic findings for HIV, and could radically shift the focus of HIV research and therapy.
引用
收藏
页码:469 / 470
页数:2
相关论文
共 12 条
[1]   Multiple measures of HIV burden in blood and tissue are correlated with each other but not with clinical parameters in aviremic subjects [J].
Anton, PA ;
Mitsuyasu, RT ;
Deeks, SG ;
Scadden, DT ;
Wagner, B ;
Huang, C ;
Macken, C ;
Richman, DD ;
Christopherson, C ;
Borellini, F ;
Lazar, R ;
Hege, KM .
AIDS, 2003, 17 (01) :53-63
[2]   CD4+ T cell depletion during all stages of HIV disease occurs predominantly in the gastrointestinal tract [J].
Brenchley, JM ;
Schacker, TW ;
Ruff, LE ;
Price, DA ;
Taylor, JH ;
Beilman, GJ ;
Nguyen, PL ;
Khoruts, A ;
Larson, M ;
Haase, AT ;
Douek, DC .
JOURNAL OF EXPERIMENTAL MEDICINE, 2004, 200 (06) :749-759
[3]   Early antiretroviral therapy for simian immunodeficiency virus infection leads to mucosal CD4+ T-Cell restoration and enhanced gene expression regulating mucosal repair and regeneration [J].
George, MD ;
Reay, E ;
Sankaran, S ;
Dandekar, S .
JOURNAL OF VIROLOGY, 2005, 79 (05) :2709-2719
[4]   Severe CD4+ T-cell depletion in gut lymphoid tissue during primary human immunodeficiency virus type 1 infection and substantial delay in restoration following highly active antiretroviral therapy [J].
Guadalupe, M ;
Reay, E ;
Sankaran, S ;
Prindiville, T ;
Flamm, J ;
McNeil, A ;
Dandekar, S .
JOURNAL OF VIROLOGY, 2003, 77 (21) :11708-11717
[5]  
LACKNER AA, 1994, AM J PATHOL, V145, P428
[6]   Peak SIV replication in resting memory CD4+ T cells depletes gut lamina propria CD4+ T cells [J].
Li, QS ;
Duan, LJ ;
Estes, JD ;
Ma, ZM ;
Rourke, T ;
Wang, YC ;
Reilly, C ;
Carlis, J ;
Miller, CJ ;
Haase, AT .
NATURE, 2005, 434 (7037) :1148-1152
[7]   Massive infection and loss of memory CD4+ T cells in multiple tissues during acute SIV infection [J].
Mattapallil, JJ ;
Douek, DC ;
Hill, B ;
Nishimura, Y ;
Martin, M ;
Roederer, M .
NATURE, 2005, 434 (7037) :1093-1097
[8]   Primary HIV-1 infection is associated with preferential depletion of CD4+ T lymphocytes from effector sites in the gastrointestinal tract [J].
Mehandru, S ;
Poles, MA ;
Tenner-Racz, K ;
Horowitz, A ;
Hurley, A ;
Hogan, C ;
Boden, D ;
Racz, P ;
Markowitz, M .
JOURNAL OF EXPERIMENTAL MEDICINE, 2004, 200 (06) :761-770
[9]   Insufficient production and tissue delivery of CD4+ memory T cells in rapidly progressive simian immunodeficiency virus infection [J].
Picker, LJ ;
Hagen, SI ;
Lum, R ;
Reed-Inderbitzin, EF ;
Daly, LM ;
Sylwester, AW ;
Walker, JM ;
Siess, DC ;
Piatak, M ;
Wang, CX ;
Allison, DB ;
Maino, VC ;
Lifson, JD ;
Kodama, T ;
Axthelm, MK .
JOURNAL OF EXPERIMENTAL MEDICINE, 2004, 200 (10) :1299-1314
[10]   Identifying the target cell in primary simian immunodeficiency virus (SIV) infection:: Highly activated memory CD4+ T cells are rapidly eliminated in early SIV infection in vivo [J].
Veazey, RS ;
Tham, IC ;
Mansfield, KG ;
DeMaria, M ;
Forand, AE ;
Shvetz, DE ;
Chalifoux, LV ;
Sehgal, PK ;
Lackner, AA .
JOURNAL OF VIROLOGY, 2000, 74 (01) :57-64