Role of the M1 receptor in regulating circadian rhythms

被引：25

作者：

Gillette, MU

Buchanan, GF

Artinian, L

Hamilton, SE

Nathanson, NM

Liu, C

机构：

[1] Univ Illinois, Dept Cell & Struct Biol, Urbana, IL 61801 USA

[2] Univ Illinois, Dept Mol & Integrat Physiol, Urbana, IL 61801 USA

[3] Univ Illinois, Neurosci Program, Urbana, IL 61801 USA

[4] Univ Illinois, Coll Med, Urbana, IL 61801 USA

[5] Univ Washington, Sch Med, Dept Pharmacol, Seattle, WA 98195 USA

来源：

LIFE SCIENCES | 2001年 / 68卷 / 22-23期

关键词：

acetylcholine; cGMP/PKG signaling; circadian rhythms; muscarinic receptors; suprachiasmatic nucleus;

D O I：

10.1016/S0024-3205(01)01040-2

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Cholinergic stimuli are potent regulators of the circadian clock in the hypothalamic suprachiasmatic nucleus (SCN). Using a brain slice model, we have found that the SCN clock is subject to muscarinic regulation, a sensitivity expressed only during the night of the clock's 24-h cycle. Pharmacological and signal transduction characteristics are compatible with a response mediated by an M-1-like receptor. Molecular manipulation of muscarinic receptors will provide important insights as to the receptor subtype(s) regulating circadian rhythms. (C) 2001 Elsevier Science Inc. All rights reserved.

引用

页码：2467 / 2472

页数：6

共 24 条

[1] Daily variation of muscarinic receptors in visual cortex but not suprachiasmatic nucleus of Syrian hamsters [J].