Methamphetamine-induced increase in striatal NF-κB DNA-binding activity is attenuated in superoxide dismutase transgenic mice

被引：49

作者：

Asanuma, M ^{[1
]}

Cadet, JL ^{[1
]}

机构：

[1] NIDA, Intramural Res Program, Mol Neuropsychiat Sect, NIH, Baltimore, MD USA

来源：

MOLECULAR BRAIN RESEARCH | 1998年 / 60卷 / 02期

关键词：

transcription factor; NF-kappa B; methamphetamine; superoxide dismutase; transgenic mice; reactive oxygen species;

D O I：

10.1016/S0169-328X(98)00188-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Methamphetamine injection (X4 with 2-h interval) caused dose-dependent activation of striatal NF-kappa B activity. Striatal NF-kappa B binding increased significantly at 1-3 h after the last injection of methamphetamine (10 mg/kg, i.p. X4). This induction of striatal NF-kappa B activity was significantly attenuated in Cu,Zn-superoxide dismutase transgenic mice in a gene dosage-dependent fashion. The present results suggest that reactive oxygen species generated by methamphetamine injections can activate striatal NF-kappa B DNA-binding during this drug-induced toxic process. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

页码：305 / 309

页数：5

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