Production of 1,3-propanediol by Clostridium butyricum DSM 5431 and product tolerant mutants in fedbatch culture: Feeding strategy for glycerol and ammonium

被引：66

作者：

Reimann, A

Biebl, H

机构：

[1] GBF - National Research Centre for Biotechnology, Biochemical Engineering Division, D-38124 Braunschweig

来源：

BIOTECHNOLOGY LETTERS | 1996年 / 18卷 / 07期

关键词：

D O I：

10.1007/BF00127897

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A fedbatch strategy was developed coupling the feeding of the two inhibitory substrates glycerol and ammonium to alkali consumption. A continuous, automated substrate addition was achieved responding directly to the needs of the culture. Thus substrate concentrations were kept on a constant low, but non limiting level. The feeding was applied for the cultivation of Clostridium butyricum DSM 5431 and mutants with increased product tolerance. Compared to fedbatch cultivations with intermittent feeding cultivation times were considerably shortened.

引用

页码：827 / 832

页数：6

共 7 条

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