Haematological malignancies: at the forefront of immunotherapeutic innovation

被引：67

作者：

Bachireddy, Pavan ^{[1
,2
,3
,4
]}

Burkhardt, Ute E. ^{[1
,2
]}

Rajasagi, Mohini ^{[1
,2
,3
]}

Wu, Catherine J. ^{[1
,2
,3
,4
]}

机构：

[1] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02215 USA

[2] Dana Farber Canc Inst, Canc Vaccine Ctr, Boston, MA 02215 USA

[3] Broad Inst, Cambridge, MA 02142 USA

[4] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Med, Boston, MA 02115 USA

来源：

NATURE REVIEWS CANCER | 2015年 / 15卷 / 04期

关键词：

CHRONIC LYMPHOCYTIC-LEUKEMIA; ACUTE MYELOID-LEUKEMIA; REGULATORY T-CELLS; WT1 PEPTIDE VACCINATION; PHASE-II TRIAL; COLONY-STIMULATING FACTOR; MONOCLONAL-ANTIBODY THERAPY; AUTOLOGOUS DENDRITIC CELLS; MESENCHYMAL STROMAL CELLS; TUMOR-ASSOCIATED ANTIGENS;

D O I：

10.1038/nrc3907

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

The recent successes of cancer immunotherapies have stimulated interest in the potential widespread application of these approaches; haematological malignancies have provided both initial proofs of concept and an informative testing ground for various immune-based therapeutics. The immune-cell origin of many of the blood malignancies provides a unique opportunity both to understand the mechanisms of cancer immune responsiveness and immune evasion, and to exploit these mechanisms for therapeutic purposes.

引用

页码：201 / 215

页数：15

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