Correlation of GDF5 and connexin 43 mRNA expression during embryonic development

被引：22

作者：

Coleman, CM

Loredo, GA

Lo, CW

Tuan, RS

机构：

[1] NIAMSD, Cartilage Biol & Orthopaed Branch, NIH, Dept Hlth & Human Serv, Bethesda, MD 20892 USA

[2] NHLBI, Dev Biol Lab, NIH, Dept Hlth & Human Serv, Bethesda, MD 20892 USA

[3] Univ Penn, Dept Biol, Philadelphia, PA 19104 USA

[4] Thomas Jefferson Univ, Dept Orthopaed Surg, Philadelphia, PA 19107 USA

来源：

ANATOMICAL RECORD PART A-DISCOVERIES IN MOLECULAR CELLULAR AND EVOLUTIONARY BIOLOGY | 2003年 / 275A卷 / 02期

关键词：

growth/differentiation factor 5; connexin; 43; chondrogenesis; heart development; spine development; tendon development;

D O I：

10.1002/ar.a.10125

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

Growth/differentiation factor 5 (GDF5) regulates connexin expression and enhances embryonic chondrogenesis in a gap junction-dependent manner, suggesting that GDF5 action on developmental skeletogenesis is coordinated with gap junction activities. The results shown here demonstrate concordance between the mRNA expression profiles of GDF5 and the gap junction gene, Cx43, in the mouse embryonic limb, spine, and heart, consistent with coordinated functions for these gene products during developmental organogenesis. (C) 2003 Wiley-Liss, Inc.

引用

页码：1117 / 1121

页数：5

共 31 条

[1] ALLEN F, 1990, DEVELOPMENT, V108, P623
[2] CHANG SC, 1994, J BIOL CHEM, V269, P28227
[3] BMP regulation of the mouse connexin43 promoter in osteoblastic cells and embryos
Chatterjee, B
Meyer, RA
Loredo, GA
Coleman, CM
Tuan, R
Lo, CW
[J]. CELL COMMUNICATION AND ADHESION, 2003, 10 (01) : 37 - 50
[4] Clarkson D, 2000, J INST BRIT TELECOMM, V1, P5
[5] GAP JUNCTIONAL COMMUNICATION DURING LIMB CARTILAGE DIFFERENTIATION
COELHO, CND
KOSHER, RA
[J]. DEVELOPMENTAL BIOLOGY, 1991, 144 (01) : 47 - 53
[6] A GRADIENT OF GAP JUNCTIONAL COMMUNICATION ALONG THE ANTERIOR POSTERIOR AXIS OF THE DEVELOPING CHICK LIMB BUD
COELHO, CND
KOSHER, RA
[J]. DEVELOPMENTAL BIOLOGY, 1991, 148 (02) : 529 - 535
[7] Growth/differentiation factor 5 enhances chondrocyte maturation
Coleman, CM
Tuan, RS
[J]. DEVELOPMENTAL DYNAMICS, 2003, 228 (02) : 208 - 216
[8] Functional role of growth/differentiation factor 5 in chondrogenesis of limb mesenchymal cells
Coleman, CM
Tuan, RS
[J]. MECHANISMS OF DEVELOPMENT, 2003, 120 (07) : 823 - 836
[9] EXPRESSION PATTERNS OF MESSENGER-RNAS FOR THE GAP JUNCTION PROTEINS CONNEXIN43 AND CONNEXIN42 SUGGEST THEIR INVOLVEMENT IN CHICK LIMB MORPHOGENESIS AND SPECIFICATION OF THE ARTERIAL VASCULATURE
DEALY, CN
BEYER, EC
KOSHER, RA
[J]. DEVELOPMENTAL DYNAMICS, 1994, 199 (02) : 156 - 167
[10] Gap junctions and biophysical regulation of bone cell differentiation
Donahue, HJ
[J]. BONE, 2000, 26 (05) : 417 - 422

← 1 2 3 4 →