Adipose-Derived Stem Cells and Their Potential to Differentiate into the Epithelial Lineage

被引:64
作者
Baer, Patrick C. [1 ]
机构
[1] Goethe Univ Frankfurt, Div Nephrol, Dept Internal Med 3, D-60590 Frankfurt, Germany
关键词
IN-VITRO DIFFERENTIATION; MESENCHYMAL STROMAL CELLS; IMPROVE POSTNATAL NEOVASCULARIZATION; PROCESSED LIPOASPIRATE CELLS; SERUM-FREE CULTURE; HEPATOCYTE DIFFERENTIATION; ENDOTHELIAL-CELLS; TISSUE; THERAPY; HETEROGENEITY;
D O I
10.1089/scd.2011.0086
中图分类号
Q813 [细胞工程];
学科分类号
摘要
Adipose-derived stem cells (ASCs) possess a multilineage differentiation potential, can be used from an autologous origin, and are, therefore, attractive candidates for clinical applications to repair or regenerate damaged tissues and organs. Adipose tissue as a stem cell source is ubiquitously available and has several advantages compared with other sources. It is easily accessible in large quantities with a minimal invasive harvesting procedure, and the isolation of ASCs yields a high amount of stem cells, which is essential for stem cell-based therapies and tissue engineering. Differentiation of ASCs into cell types of mesodermal origin has been shown in a variety of studies. The plasticity of ASCs toward cells of the mesodermal lineage has been shown by their differentiation into chondrocytes, osteoblasts, adipocytes, and myocytes. Their potential to differentiate into lineages with nonmesodermal origin is even more exciting: ASCs are also able to differentiate into cells of ecto- and endodermal origin. Various in vitro and in vivo studies documented the induced differentiation into neural cells, hepatocytes, pancreatic islet cells, endothelial cells, and epithelial cells. Epithelial cells can embryologically arise from each of the 3 germ layers. This article summarizes and discusses the current knowledge of the potential of ASCs to differentiate into the epithelial lineage. The differentiation of ASCs into different types of epithelial cells, including hepatocytes, pancreatic cells, and endothelial cells, is highlighted together with a view on current clinical trials and future options.
引用
收藏
页码:1805 / 1816
页数:12
相关论文
共 129 条
[1]   In vitro differentiation of human processed lipoaspirate cells into early neural progenitors [J].
Ashjian, PH ;
Elbarbary, AS ;
Edmonds, B ;
DeUgarte, D ;
Zhu, M ;
Zuk, PA ;
Lorenz, HP ;
Benhaim, P ;
Hedrick, MH .
PLASTIC AND RECONSTRUCTIVE SURGERY, 2003, 111 (06) :1922-1931
[2]   Hepatocyte differentiation of mesenchymal stem cells from human adipose tissue in vitro promotes hepatic integration in vivo [J].
Aurich, H. ;
Sgodda, M. ;
Kaltwasser, P. ;
Vetter, M. ;
Weise, A. ;
Liehr, T. ;
Brulport, M. ;
Hengstler, J. G. ;
Dollinger, M. M. ;
Fleig, W. E. ;
Christ, B. .
GUT, 2009, 58 (04) :570-581
[3]   Yield of human adipose-derived adult stem cells from liposuction aspirates [J].
Aust, L ;
Devlin, B ;
Foster, SJ ;
Halvorsen, YDC ;
Hicok, K ;
du Laney, T ;
Sen, A ;
Willingmyre, GD ;
Gimble, JM .
CYTOTHERAPY, 2004, 6 (01) :7-14
[4]   Conditioned medium from renal tubular epithelial cells initiates differentiation of human mesenchymal stem cells [J].
Baer, P. C. ;
Bereiter-Hahn, J. ;
Missler, C. ;
Brzoska, M. ;
Schubert, R. ;
Gauer, S. ;
Geiger, H. .
CELL PROLIFERATION, 2009, 42 (01) :29-37
[5]  
Baer PC, 2011, METHODS MOL BIOL, V702, P289, DOI 10.1007/978-1-61737-960-4_21
[6]   Human adipose-derived mesenchymal stem cells in vitro: evaluation of an optimal expansion medium preserving stemness [J].
Baer, Patrick C. ;
Griesche, Nadine ;
Luttmann, Werner ;
Schubert, Ralf ;
Luttmann, Arlette ;
Geiger, Helmut .
CYTOTHERAPY, 2010, 12 (01) :96-106
[7]   Preadipocyte number in omental and subcutaneous adipose tissue of obese individuals [J].
Bakker, AHF ;
van Dielen, FMH ;
Greve, JWM ;
Adam, JA ;
Buurman, WA .
OBESITY RESEARCH, 2004, 12 (03) :488-498
[8]   IFATS Collection: In Vivo Therapeutic Potential of Human Adipose Tissue Mesenchymal Stem Cells After Transplantation into Mice with Liver Injury [J].
Banas, Agnieszka ;
Teratani, Takumi ;
Yamamoto, Yusuke ;
Tokuhara, Makoto ;
Takeshita, Fumitaka ;
Osaki, Mitsuhiko ;
Kawamata, Masaki ;
Kato, Takashi ;
Okochi, Hitoshi ;
Ochiya, Takahiro .
STEM CELLS, 2008, 26 (10) :2705-2712
[9]   Adipose tissue-derived mesenchymal stem cells as a source of human hepatocytes [J].
Banas, Agnieszka ;
Teratani, Takumi ;
Yamamoto, Yusuke ;
Tokuhara, Makoto ;
Takeshita, Fumitaka ;
Quinn, Gary ;
Okochi, Hitoshi ;
Ochiya, Takahiro .
HEPATOLOGY, 2007, 46 (01) :219-228
[10]   Rapid hepatic fate specification of adipose-derived stem cells and their therapeutic potential for liver failure [J].
Banas, Agnieszka ;
Teratani, Takumi ;
Yamamoto, Yusuke ;
Tokuhara, Makoto ;
Takeshita, Fumitaka ;
Osaki, Mitsuhiko ;
Kato, Takashi ;
Okochi, Hitoshi ;
Ochiya, Takahiro .
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2009, 24 (01) :70-77