Synthesis of C-Pseudonucleosides Bearing Thiazolidin-4-one as a Novel Potential Immunostimulating Agent

被引：26

作者：

Chen, Hua ^{[1
]}

Yin, Qingmei ^{[1
]}

Li, Chunxiao ^{[2
]}

Wang, Enkai ^{[1
]}

Gao, Fang ^{[1
]}

Zhang, Xiaobo ^{[1
]}

Yin, Zhi ^{[1
]}

Wei, Sinan ^{[1
]}

Li, Xiaoliu ^{[1
,3
]}

Meng, Ming ^{[2
]}

Zhang, Pingzhu ^{[1
]}

Li, Na ^{[2
]}

Zhang, Jinchao ^{[1
]}

机构：

[1] Hebei Univ, Key Lab Chem Biol Hebei Prov, Coll Chem & Environm Sci, Baoding 071002, Peoples R China

[2] Hebei Univ, Sch Med, Baoding 071002, Peoples R China

[3] Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

来源：

ACS MEDICINAL CHEMISTRY LETTERS | 2011年 / 2卷 / 11期

基金：

中国国家自然科学基金;

关键词：

Immunostimulating agents; C-pseudonucleosides; thiazolidin-4-one; NUCLEOSIDE ANALOGS; IMMUNE;

D O I：

10.1021/ml200155k

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

Several novel C-pseudonucleosides bearing thiazolidin-4-one were synthesized by one-pot three-component condensation using unprotected sugar aldehyde at room temperature, and their effects on T cells, B cells, the cytokine secretion of IL-2, IL-4, and IFN-gamma, T cell-associated molecules (CD3, CD4, CD8), and B cell-associated molecules (CD 19) were first evaluated. The experimental data demonstrated that such thiazolidin-4-one C-pseudonucleosides hold potential as immunostimulating agents.

引用

页码：845 / 848

页数：4

共 24 条

[1]

Synthesis of C-(D-glycopyranosyl)ethylamines and C-(D-glycofuranosyl)methylamines as potential glycosidase inhibitors [J].