From Sulfenylation to Sulfhydration: What a Thiolate Needs to Tolerate

被引：118

作者：

Finkel, Toren ^{[1
]}

机构：

[1] NHLBI, Ctr Mol Med, NIH, Bethesda, MD 20892 USA

来源：

SCIENCE SIGNALING | 2012年 / 5卷 / 215期

关键词：

ENDOPLASMIC-RETICULUM STRESS; TYROSINE-PHOSPHATASE; 1B; HYDROGEN-PEROXIDE; OXIDATION; H2S; INACTIVATION; VASORELAXANT; GENERATION; CYSTEINE; SULFIDE;

D O I：

10.1126/scisignal.2002943

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

There is a growing appreciation that oxidants such as hydrogen peroxide (H2O2) and gasses such as nitric oxide (NO) and hydrogen sulfide (H2S) can act as modulators of various signaling pathways. Much of this signaling occurs through the modifications of specific, critical cysteine residues in target proteins. How such small diffusible molecules (H2O2, NO, H2S) can achieve the required specificity is incompletely understood. Now, new findings provide considerable insight into these and related questions.

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