Etiology of ovarian cancer: a proposed mechanism

被引:39
作者
Ghahremani, M [1 ]
Foghi, A [1 ]
Dorrington, JH [1 ]
机构
[1] Univ Toronto, Charles H Best Inst, Banting & Best Dept Med Res, Toronto, ON M5G 1L6, Canada
关键词
D O I
10.1054/mehy.1997.0620
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
The majority of ovarian cancers are derived from ovarian surface epithelial cells that are sequestered in inclusion cysts within the ovarian stroma. We propose that the Fas/Fas ligand system is responsible for the normal elimination of these inclusion cysts through apoptosis, thereby removing potential sites of ovarian tumors. Furthermore, we hypothesize that the failure of the Fas/Fas ligand's apoptotic signaling mechanism leads to the persistence of these inclusion cysts in the stroma, and the onset of ovarian tumorigenesis.
引用
收藏
页码:23 / 26
页数:4
相关论文
共 19 条
[1]   FOLLICULAR STIMULATION AND OVARIAN-CANCER [J].
BALASCH, J ;
BARRI, PN .
HUMAN REPRODUCTION, 1993, 8 (07) :990-996
[2]  
BELL DA, 1994, CANCER, V73, P1859, DOI 10.1002/1097-0142(19940401)73:7<1859::AID-CNCR2820730714>3.0.CO
[3]  
2-L
[4]  
CRAMER DW, 1983, JNCI-J NATL CANCER I, V71, P717
[5]  
FATHALLA MF, 1971, LANCET, V2, P163
[6]  
FOGHI A, UNPUB FAS INDUCED AP
[7]  
GHAHREMANI M, UNPUB ACTIVATION FAS
[8]  
GREENE MH, 1984, SEMIN ONCOL, V11, P209
[9]   IDENTIFICATION OF FAS ANTIGEN ASSOCIATED WITH APOPTOTIC CELL-DEATH IN MURINE OVARY [J].
GUO, MW ;
MORI, E ;
XU, JP ;
MORI, T .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1994, 203 (03) :1438-1446
[10]  
HAKUNO N, 1996, ENDOCRINOLOGY, V137, P1398