Physiological roles revealed by ghrelin and ghrelin receptor deficient mice

被引：43

作者：

Albarran-Zeckler, Rosie G. ^{[1
,2
]}

Sun, Yuxiang ^{[2
,3
]}

Smith, Roy G. ^{[1
,2
]}

机构：

[1] Scripps Res Inst Florida, Dept Metab & Aging, Jupiter, FL 33458 USA

[2] Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX 77030 USA

[3] Childrens Nutr Res Ctr, Houston, TX 77030 USA

来源：

PEPTIDES | 2011年 / 32卷 / 11期

关键词：

Ghrelin; Ghrelin receptor (GHS-R1a); Ghrein knockout mice; Ghrelin receptor knockout mice; GROWTH-HORMONE SECRETAGOGUE; PARKINSONS-DISEASE; FOOD-INTAKE; ENERGY-BALANCE; KNOCKOUT MICE; RELEASE; PITUITARY; OBESITY; APPETITE; RATS;

D O I：

10.1016/j.peptides.2011.07.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Ghrelin is a hormone made in the stomach and known primarily for its growth hormone releasing and orexigenic properties. Nevertheless, ghrelin through its receptor, the GHS-R1a, has been shown to exert many roles including regulation of glucose homeostasis, memory & learning, food addiction and neuroprotection. Furthermore, ghrelin could promote overall health and longevity by acting directly in the immune system and promoting an extended antigen repertoire. The development of mice lacking either ghrelin (ghrelin-/-) or its receptor (ghsr-/-) have provided a valuable tool for determining the relevance of ghrelin and its receptor in these multiple and diverse roles. In this review, we summarize the most important findings and lessons learned from the ghrelin-/- and ghsr-/- mice. Published by Elsevier Inc.

引用

页码：2229 / 2235

页数：7

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