Effect of membrane dialysis on characteristics of lyophilised chitosan wafers for potential buccal delivery of proteins

被引：24

作者：

Ayensu, Isaac ^{[1
,2
]}

Mitchell, John C. ^{[1
]}

Boateng, Joshua S. ^{[1
]}

机构：

[1] Univ Greenwich Medway, Sch Sci, Dept Pharmaceut Chem & Environm Sci, Chatham ME4 4TB, Kent, England

[2] Kwame Nkrumah Univ Sci & Technol, Fac Pharm & Pharmaceut Sci, Dept Pharmaceut Chem, Kumasi, Ghana

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2012年 / 50卷 / 04期

关键词：

Buccal delivery; Chitosan; Lyophilised wafers; Membrane dialysis; Mucoadhesion; Protein delivery; IN-VIVO EVALUATION; DRUG-DELIVERY; CHEMICAL-MODIFICATION; SYSTEMS; CHITIN;

D O I：

10.1016/j.ijbiomac.2012.02.014

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effect of membrane dialysis on the characteristics of chitosan based lyophilised wafers was investigated. Gels loaded with BSA, glycerol and p-mannitol were lyophilised with or without membrane dialysis and characterised by X-ray diffraction, attenuated total reflectance Fourier transform infra red spectroscopy, circular dichroism, scanning electron microscopy, hydration capacity, in vitro mucoadhesivity and drug dissolution. The dialysed wafers demonstrated enhanced mucoadhesion and drug release properties while newly formed sodium acetate in the undialysed wafers caused increased crystallinity with poor mucoadhesion and drug release properties. Removal of sodium acetate by membrane dialysis is essential for obtaining optimised wafers for potential application to the buccal mucosa surface. (C) 2012 Elsevier B.V. All rights reserved.```

引用

页码：905 / 909

页数：5

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