Aerobic Exercise Improves Cognition for Older Adults with Glucose Intolerance, A Risk Factor for Alzheimer's Disease

被引:191
作者
Baker, Laura D. [1 ,8 ]
Frank, Laura L. [1 ,8 ]
Foster-Schubert, Karen [2 ,3 ]
Green, Pattie S. [2 ,4 ]
Wilkinson, Charles W. [1 ,8 ]
McTiernan, Anne [2 ,3 ]
Cholerton, Brenna A. [1 ,8 ]
Plymate, Stephen R. [2 ,8 ]
Fishel, Mark A. [5 ,8 ]
Watson, G. Stennis [1 ,8 ]
Duncan, Glen E. [6 ]
Mehta, Pankaj D. [7 ]
Craft, Suzanne [1 ,8 ]
机构
[1] Univ Washington, Sch Med, Dept Psychiat & Behav Sci, Seattle, WA 98195 USA
[2] Univ Washington, Sch Med, Dept Med, Seattle, WA 98195 USA
[3] Fred Hutchinson Canc Res Ctr, Canc Prevent Res Program, Seattle, WA 98104 USA
[4] Vet Affairs Puget Sound Hlth Care Syst, Res & Dev, Seattle, WA USA
[5] Univ Washington, Sch Med, Dept Neurol, Seattle, WA USA
[6] Univ Washington, Sch Publ Hlth, Dept Epidemiol, Nutr Sci Program, Seattle, WA 98195 USA
[7] New York State Inst Basic Res Dev Disabil, Dept Immunol, New York, NY USA
[8] VA Puget Sound Hlth Care Syst, Ctr Geriatr Res Educ & Clin, Seattle, WA 98108 USA
关键词
Aerobic exercise; Alzheimer's disease; cognition; dementia; diabetes; executive function; glucose intolerance; prediabetes; INSULIN-RESISTANCE SYNDROME; EXECUTIVE DYSFUNCTION; NEUROTROPHIC FACTOR; ELDERLY POPULATION; PHYSICAL-ACTIVITY; FRONTAL-LOBE; DEMENTIA; IMPAIRMENT; PERFORMANCE; MEMORY;
D O I
10.3233/JAD-2010-100768
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Impaired glucose regulation is a defining characteristic of type 2 diabetes mellitus (T2DM) pathology and has been linked to increased risk of cognitive impairment and dementia. Although the benefits of aerobic exercise for physical health are well-documented, exercise effects on cognition have not been examined for older adults with poor glucose regulation associated with prediabetes and early T2DM. Using a randomized controlled design, twenty-eight adults (57-83 y old) meeting 2-h tolerance test criteria for glucose intolerance completed 6 months of aerobic exercise or stretching, which served as the control. The primary cognitive outcomes included measures of executive function (Trails B, Task Switching, Stroop, Self-ordered Pointing Test, and Verbal Fluency). Other outcomes included memory performance (Story Recall, List Learning), measures of cardiorespiratory fitness obtained via maximal-graded exercise treadmill test, glucose disposal during hyperinsulinemic-euglycemic clamp, body fat, and fasting plasma levels of insulin, cortisol, brain-derived neurotrophic factor, insulin-like growth factor-1, amyloid-beta (A beta(40) and A beta(42)). Six months of aerobic exercise improved executive function (MANCOVA, p = 0.04), cardiorespiratory fitness (MANOVA, p = 0.03), and insulin sensitivity (p = 0.05). Across all subjects, 6-month changes in cardiorespiratory fitness and insulin sensitivity were positively correlated (p = 0.01). For A beta(42), plasma levels tended to decrease for the aerobic group relative to controls (p = 0.07). The results of our study using rigorous controlled methodology suggest a cognition-enhancing effect of aerobic exercise for older glucose intolerant adults. Although replication in a larger sample is needed, our findings potentially have important therapeutic implications for a growing number of adults at increased risk of cognitive decline.
引用
收藏
页码:569 / 579
页数:11
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