学术探索
学术期刊
新闻热点
数据分析
智能评审

T cell homeostasis: Keeping useful T cells alive and live T cells useful

被引：101
作者：
Jameson, SC [1 ]
机构：
[1] Univ Minnesota, Sch Med, Ctr Immunol, Minneapolis, MN 55455 USA
[2] Univ Minnesota, Sch Med, Dept Lab Med & Pathol, Minneapolis, MN 55455 USA
来源：
SEMINARS IN IMMUNOLOGY | 2005年 / 17卷 / 03期
关键词：
memory T cells; naive T cells; cytokines; TCR; peptide/MHC;
D O I：
10.1016/j.smim.2005.02.003
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
It has become clear that the regulation of T cell numbers is under peripheral homeostatic control. However, the rules for homeostasis vary with the T cells' differentiation state and the overall T cell number in the animal. Furthermore, homeostatic pressures can cause unexpected changes in T cell differentiation and function which might promote or dampen T cell reactivity. In this review, we focus on the role of peptide/MHC and cytokine interactions in regulating the size and composition of the T cell pool. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码：231 / 237
页数：7
相关论文
共 106 条
  • [1] Homeostasis of intestinal immune regulation
    Annacker, O
    Powrie, F
    [J]. MICROBES AND INFECTION, 2002, 4 (05) : 567 - 574
  • [2] CD8+ T cell contraction is controlled by early inflammation
    Badovinac, VP
    Porter, BB
    Harty, JT
    [J]. NATURE IMMUNOLOGY, 2004, 5 (08) : 809 - 817
  • [3] CD8+ T-cell homeostasis after infection:: setting the 'curve'
    Badovinac, VP
    Harty, JT
    [J]. MICROBES AND INFECTION, 2002, 4 (04) : 441 - 447
  • [4] T cell regulation as a side effect of homeostasis and competition
    Barthlott, T
    Kassiotis, G
    Stockinger, B
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 197 (04) : 451 - 460
  • [5] Interleukin 15 is required for proliferative renewal of virus-specific memory CD8 T cells
    Becker, TC
    Wherry, EJ
    Boone, D
    Murali-Krishna, K
    Antia, R
    Ma, A
    Ahmed, R
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2002, 195 (12) : 1541 - 1548
  • [6] A central role for thymic emigrants in peripheral T cell homeostasis
    Berzins, SP
    Godfrey, DI
    Miller, JFAP
    Boyd, RL
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (17) : 9787 - 9791
  • [7] Thymic regeneration: teaching an old immune system new tricks
    Berzins, SP
    Uldrich, AP
    Sutherland, JS
    Gill, J
    Miller, JFAP
    Godfrey, DI
    Boyd, RL
    [J]. TRENDS IN MOLECULAR MEDICINE, 2002, 8 (10) : 469 - 476
  • [8] The role of the thymus and recent thymic migrants in the maintenance of the adult peripheral lymphocyte pool
    Berzins, SP
    Boyd, RL
    Miller, JFAP
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 187 (11) : 1839 - 1848
  • [9] Peripheral expression of self-MHC-II influences the reactivity and self-tolerance of mature CD4+ T cells:: Evidence from a lymphopenic T cell model
    Bhandoola, A
    Tai, XG
    Eckhaus, M
    Auchincloss, H
    Mason, K
    Rubin, SA
    Carbone, KM
    Grossman, Z
    Rosenberg, AS
    Singer, A
    [J]. IMMUNITY, 2002, 17 (04) : 425 - 436
  • [10] Bourgeois C, 2002, EUR J IMMUNOL, V32, P2199, DOI 10.1002/1521-4141(200208)32:8<2199::AID-IMMU2199>3.0.CO
12345678910