CAR: A virus receptor within the tight junction

被引：177

作者：

Coyne, CB ^{[1
]}

Bergelson, JM ^{[1
]}

机构：

[1] Childrens Hosp Philadelphia, Div Infect Dis, Philadelphia, PA 19104 USA

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2005年 / 57卷 / 06期

基金：

美国国家卫生研究院;

关键词：

coxsackievirus adenovirus receptor (CAR); tight junction; junctional adhesion molecule (JAM); coxsackie virus B (CVB); adenovirus (Ad);

D O I：

10.1016/j.addr.2005.01.007

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The coxsackievirus and adenovirus receptor (CAR) mediates cell attachment and infection by coxsackie B viruses and by a number of adenoviruses. CAR also mediates homotypic intercellular interactions. In polarized epithelial cells, CAR is closely associated with the tight junction, where it contributes to the barrier to paracellular flow of solutes and macromolecules. CAR's biological roles are not well defined, but emerging evidence suggests that it may function during embryonic development and in regulating cell proliferation. (c) 2005 Elsevier B.V. All rights reserved.

引用

页码：869 / 882

页数：14

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